Late-life depression (LLD) is a multifactorial disorder, with susceptibility and vulnerability
potentially influenced by gene-environment interaction. The aim of this study was to …

Serotonin, one of the first neurotransmitters to be identified, is an evolutionarily old molecule
that is highly conserved across the animal kingdom, and widely used throughout the brain …

Purpose Recent reviews have questioned the efficacy of selective serotonin reuptake
inhibitors (SSRIs) above placebo response, and their working mechanisms remain unclear …

Objective To explore patient and health professional views and experiences of
antidepressant treatment with particular focus on barriers and facilitators to discontinuing …

We investigated if improving a patient's memory for the content of their treatment, via the
Memory Support Intervention, improves illness course and functional outcomes. The …

The interaction between the serotonin transporter (SERT) linked polymorphic region (5-
HTTLPR) and adverse early life stressing (ELS) events is associated with enhanced stress …

Objective Manic and depressive phases of bipolar disorder (BD) show opposite
psychomotor symptoms. Neuronally, these may depend on altered relationships between …

Pharmaceutical pollutants are detected in aquatic habitats and wildlife tissues globally. One
widespread contaminant of major concern is the antidepressant fluoxetine, which can affect …

Uncertainty regarding which psychological mechanisms are fundamental in mediating SSRI
treatment outcomes and wide-ranging variability in their efficacy has raised more questions …

Chronic stress induces anhedonia in susceptible but not resilient individuals, a
phenomenon observed in humans as well as animal models, but the molecular mechanisms …