Inflammasomes in alveolar bone loss

Y Li, J Ling, Q Jiang - Frontiers in immunology, 2021 - frontiersin.org
Bone remodeling is tightly controlled by osteoclast-mediated bone resorption and osteoblast-
mediated bone formation. Fine tuning of the osteoclast–osteoblast balance results in strict …

The promising role of antioxidant phytochemicals in the prevention and treatment of periodontal disease via the inhibition of oxidative stress pathways: Updated …

TTT Vo, PM Chu, VP Tuan, JSL Te, IT Lee - Antioxidants, 2020 - mdpi.com
There is growing evidence on the involvement of oxidative stress, which is simply described
as the imbalance between oxidants and antioxidants in favor of the former, in the …

Porphyromonas gingivalis Promotes Colorectal Carcinoma by Activating the Hematopoietic NLRP3 Inflammasome

X Wang, Y Jia, L Wen, W Mu, X Wu, T Liu, X Liu, J Fang… - Cancer Research, 2021 - AACR
Porphyromonas gingivalis (P. gingivalis) is a keystone periodontal pathogen associated with
various digestive cancers. However, whether P. gingivalis can promote colorectal cancer …

A novel injectable piezoelectric hydrogel for periodontal disease treatment

L Roldan, C Montoya, V Solanki, KQ Cai… - … Applied Materials & …, 2023 - ACS Publications
Periodontal disease is a multifactorial, bacterially induced inflammatory condition
characterized by the progressive destruction of periodontal tissues. The successful …

Corilagin restrains NLRP3 inflammasome activation and pyroptosis through the ROS/TXNIP/NLRP3 pathway to prevent inflammation

T Luo, X Zhou, M Qin, Y Lin, J Lin… - Oxidative medicine …, 2022 - Wiley Online Library
Corilagin, a gallotannin, shows excellent antioxidant and anti‐inflammatory effects. The
NLRP3 inflammasome dysfunction has been implicated in a variety of inflammation …

Eldecalcitol inhibits LPS-induced NLRP3 inflammasome-dependent pyroptosis in human gingival fibroblasts by activating the Nrf2/HO-1 signaling pathway

C Huang, C Zhang, P Yang, R Chao, Z Yue… - Drug design …, 2020 - Taylor & Francis
Purpose Periodontitis is a major chronic oral disease that is accelerated by activation of the
NLRP3 inflammasome and the resulting pyroptosis. According to recent studies, active …

[HTML][HTML] Trem2 mediated Syk-dependent ROS amplification is essential for osteoclastogenesis in periodontitis microenvironment

Y Weng, H Wang, L Li, Y Feng, S Xu, Z Wang - Redox Biology, 2021 - Elsevier
Periodontitis is the sixth most prevalent diseases around the globe, which is closely related
to many systemic diseases and affects general health. As the leading cause of tooth loss …

PAMPs and DAMPs as the bridge between periodontitis and atherosclerosis: the potential therapeutic targets

X Zhu, H Huang, L Zhao - Frontiers in cell and developmental biology, 2022 - frontiersin.org
Atherosclerosis is a chronic artery disease characterized by plaque formation and vascular
inflammation, eventually leading to myocardial infarction and stroke. Innate immunity plays …

ROS-scavenging nanomaterials to treat periodontitis

L Sui, J Wang, Z Xiao, Y Yang, Z Yang, K Ai - Frontiers in chemistry, 2020 - frontiersin.org
The incidence of periodontitis is very high, and up to 45–50% of people are suffering from
periodontitis. Periodontitis is caused by pathogens that invade teeth-supporting tissues such …

[HTML][HTML] The role of inflammasome NLPR3 in the development and therapy of periodontitis

Y Zhao, Y Quan, T Lei, L Fan, X Ge… - International Journal of …, 2022 - ncbi.nlm.nih.gov
Periodontitis is a chronic inflammatory disease that affects tooth-supporting tissues and even
leads to tooth loss. NLRP3 inflammasomes play a critical role in periodontitis pathogenesis …