Protein therapeutics carry inherent limitations of membrane impermeability and structural
instability, despite their predominant role in the modern pharmaceutical market. Effective …

Peptides and biologics provide unique opportunities to modulate intracellular targets not
druggable by conventional small molecules. Most peptides and biologics are fused with …

Monoclonal antibodies (mAbs) and peptides are an important class of therapeutic modalities
that have brought improved health outcomes in areas with limited therapeutic optionality …

As unique biopolymers, proteins can be employed for therapeutic delivery. They bear
important features such as bioavailability, biocompatibility, and biodegradability with low …

Purpose To review the current literature to determine which injection technique and needle
portal placement provide the greatest accuracy for intra-articular access to the knee …

Mesenchymal stem cells (MSCs) have recently emerged as a promising living carrier for
targeted drug delivery. A wealth of literature has shown evidence for great advances in …

The surface modification of nanoparticles (NPs) can enhance the intracellular delivery of
drugs, proteins, and genetic agents. Here we studied the effect of different surface ligands …

Evaluating the in-use stability of a biological product including its compatibility with
administration components allows to define handling instructions and potential hold times …

Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that is characterized by
synovial inflammation, cellular infiltration in joints which leads to progressive joint …

There is a significant clinical need for rapid and efficient delivery of drugs directly to the site
of diseased tissues for the treatment of gastrointestinal (GI) pathologies, in particular …