Human T-cell lymphotropic virus type 1 (HTLV-1), causes adult T cell leukemia/lymphoma
(ATLL), and initiates a variety of immune mediated disorders. The viral genome encodes …

Robust transcription of human T-cell leukemia virus type 1 (HTLV-1) genome requires the
viral transactivator Tax. Although Tax has been previously shown to interact with the KIX …

Lysine residues are subject to a multitude of reversible post-translational modifications,
including acetylation and SUMOylation. In the heart, enhancement of lysine acetylation or …

The “chromogenome” is defined as the structural and functional status of the genome at any
given moment within a eukaryotic cell. This article focuses on recently uncovered …

The Tax protein of human T-cell leukemia virus type 1 (HTLV-1) can form homodimers. Tax
dimerization contributes to optimal Tax activity involved in transactivation of the HTLV-1 …

The human T-cell leukemia virus type 1 (HTLV-1) is integrated into the host cell DNA and
assembled into nucleosomes. Within the repressive chromatin environment, the virally …

The human T-cell leukemia virus-encoded oncoprotein Tax is a potent activator of viral
transcription. Tax function is strictly dependent upon the cellular transcription factor CREB …

Eukaryotic genomes are packaged into a dynamic hierarchy chromatin structure. In such a
particular context, the transition from a repressed compacted chromatin to a rather extended …

Viral and cellular gene expression are regulated by epigenetic alterations, including DNA
methylation, histone modifications, nucleosome positioning, and chromatin looping. Human …

The human T-cell leukemia virus type 1 (HTLV-1) regulatory proteins Tax and HBZ play
indispensable roles in regulating viral and cellular gene expression. BRG1, the ATPase …