The role of SLC transporters for brain health and disease

YTK Nguyen, HTT Ha, TH Nguyen… - Cellular and Molecular Life …, 2022 - Springer
The brain exchanges nutrients and small molecules with blood via the blood–brain barrier
(BBB). Approximately 20% energy intake for the body is consumed by the brain. Glucose is …

Glucose transporters in cardiovascular system in health and disease

L Bertrand, J Auquier, E Renguet, M Angé… - … -European Journal of …, 2020 - Springer
Glucose transporters are essential for the heart to sustain its function. Due to its nature as a
high energy-consuming organ, the heart needs to catabolize a huge quantity of metabolic …

Expression and role of p16 and GLUT1 in malignant diseases and lung cancer: a review

A Pezzuto, M D'Ascanio, A Ricci, A Pagliuca… - Thoracic …, 2020 - Wiley Online Library
Non‐small cell lung cancer (NSCLC) is the leading cause of cancer death and in most cases
it is often diagnosed at an advanced stage. Many genetic and microenvironmental factors …

[PDF][PDF] Influences of rare copy-number variation on human complex traits

MLA Hujoel, MA Sherman, AR Barton, RE Mukamel… - Cell, 2022 - cell.com
The human genome contains hundreds of thousands of regions harboring copy-number
variants (CNV). However, the phenotypic effects of most such polymorphisms are unknown …

Identifying the molecular mechanisms of sepsis-associated acute kidney injury and predicting potential drugs

G Guo, Y Wang, W Kou, H Gan - Frontiers in Genetics, 2022 - frontiersin.org
Objective: To provide insights into the diagnosis and therapy of SA-AKI via ferroptosis
genes. Methods: Based on three datasets (GSE57065, GSE30718, and GSE53771), we …

Identification and experimental validation of ferroptosis-related gene SLC2A3 is involved in rheumatoid arthritis

J Xiang, H Chen, Z Lin, J Chen, L Luo - European Journal of Pharmacology, 2023 - Elsevier
Background Ferroptosis, an iron-dependent manner of lipid peroxidative cell death, has
recently been reported to be strongly associated with rheumatoid arthritis (RA). Targeted …

[HTML][HTML] Mitochondria in early forebrain development: from neurulation to mid-corticogenesis

RM Fame, MK Lehtinen - Frontiers in Cell and Developmental Biology, 2021 - frontiersin.org
Function of the mature central nervous system (CNS) requires a substantial proportion of the
body's energy consumption. During development, the CNS anlage must maintain its …

Divergent epigenetic responses to perinatal asphyxia in severe mental disorders

LA Wortinger, AK Stavrum, AA Shadrin, A Szabo… - Translational …, 2024 - nature.com
Epigenetic modifications influenced by environmental exposures are molecular sources of
phenotypic heterogeneity found in schizophrenia and bipolar disorder and may contribute to …

In vitro assessment of inflammatory skin potential of poly(methyl methacrylate) at non‐cytotoxic concentrations

LF Barraza‐Vergara… - … Research Part A, 2023 - Wiley Online Library
Abstract Poly (methyl methacrylate)(PMMA) is considered an attractive substrate material for
fabricating wearable skin sensors such as fitness bands and microfluidic devices. Despite its …

Targeted CRISPR activation and knockout screenings identify novel doxorubicin transporters

Y Li, M Tan, S Sun, E Stea, B Pang - Cellular Oncology, 2023 - Springer
Purpose Tissue-specific drug uptake has not been well studied, compared to the deeper
understanding of drug resistance mediated by the cellular efflux system such as MDR1 …