We describe a new hypothesis for the development of autism, that it is driven by imbalances
in brain development involving enhanced effects of paternally expressed imprinted genes …

In normal mammals, autosomal genes are present in duplicate (ie two alleles), one inherited
from the father, and one from the mother. For the majority of genes both alleles are …

Imprinted genes are a subset of mammalian genes that are subject to germline parent-
specific epigenetic modifications leading monoallelic expression. Imprinted gene expression …

Parent-of-origin gene expression (genomic imprinting) is widespread among eutherian
mammals and also occurs in marsupials. Most imprinted genes are expressed in the …

Imprinted genes display parent-of-origin-specific expression with this epigenetic system of
regulation found exclusively in therian mammals. Historically, defined imprinted gene …

Pivotal to successful mammalian reproduction is the ability of a developing embryo to
implant to the uterine wall and establish a nutrient supply via placentation. Herein, we have …

The maternally expressed/paternally silenced genes Phlda2 (aka Ipl/Tssc3), Slc22a1l,
Cdkn1c, Kcnq1, and Ascl2 are clustered in an imprinted domain on mouse chromosome 7 …

Background Insulin-like growth factors 1 and 2 (IGF1 and IGF2) and their binding proteins
(IGFBPs) are expressed in the placenta and known to regulate fetal growth. DNA …

Evolutionary paradigms of human health and nutrition center on the evolutionary
discordance or “mismatch” model in which human bodies, reflecting adaptations established …

In the past decade, data from numerous epidemiological studies have indicated strong
inverse associations between birth weight and risk of coronary heart disease, hypertension …