Acute kidney injury (AKI) is a commonly encountered comorbidity in critically ill children. The
coexistence of AKI disturbs drug pharmacokinetics and pharmacodynamics, leading to …

The aim of this study was to assess the in vitro adsorption of antibiotics: vancomycin,
gentamicin, ciprofloxacin and tigecycline on both polyethyleneimine-treated polyacrylonitrile …

Introduction: The coronavirus disease 2019 (COVID-19) pandemic led to increased demand
nationwide for dialysis equipment, including supplies and machines. To meet the demand in …

OBJECTIVES: Patients with sepsis are at significant risk for multiple organ dysfunction,
including the lungs and kidneys. To manage the morbidity associated with kidney …

Abstract Meropenem, linezolid, fluconazole, voriconazole, posaconazole, and vancomycin
are six important antimicrobials used for severe infections in critically ill patients listed in …

Introduction: Critically ill patients with acute kidney injury often require renal replacement
therapy and antibiotic therapy. Mortality rates are high in these patients, possibly due to …

Background: Polymyxin B has become the last choice for patient with carbapenem-resistant
bacteria infection. However, the optimal dosing of Polymyxin B in critically ill children …

Critical illness induces pathophysiological changes that cause significant alterations to drug
pharmacokinetics and pharmacodynamics (PK-PD)[1]. PK refers to how the body handles …

Background Ceftazidime and clindamycin are commonly prescribed to critically ill patients
who require extracorporeal life support such as ECMO and CRRT. The effect of ECMO and …

Optimal antibiotic therapy for critically ill patients can be complicated by the altered
physiology associated with critical illness. Antibiotic pharmacokinetics and exposures can …