The MYC proto-oncogenes encode a family of transcription factors that are among the most
commonly activated oncoproteins in human neoplasias. Indeed, MYC aberrations or …

Cancer has myriad effects on metabolism that include both rewiring of intracellular
metabolism to enable cancer cells to proliferate inappropriately and adapt to the tumor …

Since cancer stem cells (CSCs) were first identified in leukemia in 1994, they have been
considered promising therapeutic targets for cancer therapy. These cells have self-renewal …

The development of precision medicine approaches for diffuse large B cell lymphoma
(DLBCL) is confounded by its pronounced genetic, phenotypic, and clinical heterogeneity …

Ribosome biogenesis and protein synthesis are fundamental rate-limiting steps for cell
growth and proliferation. The ribosomal proteins (RPs), comprising the structural parts of the …

Metabolic reprogramming enables cancer cell growth, proliferation, and survival. This
reprogramming is driven by the combined actions of oncogenic alterations in cancer cells …

Cancer cells must rewire cellular metabolism to satisfy the demands of unbridled growth and
proliferation. As such, most human cancers differ from normal counterpart tissues by a …

Small molecules that directly target MYC and are also well tolerated in vivo will provide
invaluable chemical probes and potential anti-cancer therapeutic agents. We developed a …

Mitochondrial respiration is critical for cell proliferation. In addition to producing ATP,
respiration generates biosynthetic precursors, such as aspartate, an essential substrate for …

The MYC protooncogene functions as a universal amplifier of transcription through
interaction with numerous factors and complexes that regulate almost every cellular process …