The large Trp gene family encodes transient receptor potential (TRP) proteins that form
novel cation-selective ion channels. In mammals, 28 Trp channel genes have been …

Ion channels are important therapeutic targets due to their plethoric involvement in
physiological and pathological consequences. The transient receptor potential cation …

ThermoTRP channels (thermoTRPs) define a subfamily of the transient receptor potential
(TRP) channels that are activated by changes in the environmental temperature, from …

Of somatosensory modalities, cold is one of the more ambiguous percepts, evoking the
pleasant sensation of cooling, the stinging bite of cold pain, and welcome relief from chronic …

Cancer is one of the most common causes of death worldwide, and its development is a
result of the complex interaction of genetic factors, environmental cues, and aging. Hormone …

Cancer cells proliferate, differentiate and migrate by repurposing physiological signalling
mechanisms. In particular, altered calcium signalling is emerging as one of the most …

Breast cancer is one of the most frequent cancer types worldwide and the first cause of
cancer-related deaths in women. Although significant therapeutic advances have been …

The goal of this article is to provide a critical review of the transient receptor potential
melastatin-subfamily member 8 (TRPM8) in cancers, with an emphasis on its roles in cellular …

Transient receptor potential melastatin 8 (TRPM8) was originally cloned from prostate tissue.
Shortly thereafter, the protein was identified as a cold-and menthol-activated ion channel in …

The Transient Receptor Potential (TRP) channels family consists of seven different
subfamilies, namely TRPC (Canonical), TRPV (Vanilloid), TRPM (Melastatin), TRPML …