Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia
MB Pappalardi, K Keenan, M Cockerill, WA Kellner… - Nature cancer, 2021 - nature.com
DNA methylation, a key epigenetic driver of transcriptional silencing, is universally
dysregulated in cancer. Reversal of DNA methylation by hypomethylating agents, such as …
dysregulated in cancer. Reversal of DNA methylation by hypomethylating agents, such as …
Identification of tumor antigens with immunopeptidomics
C Chong, G Coukos, M Bassani-Sternberg - Nature biotechnology, 2022 - nature.com
The identification of actionable tumor antigens is indispensable for the development of
several cancer immunotherapies, including T cell receptor–transduced T cells and patient …
several cancer immunotherapies, including T cell receptor–transduced T cells and patient …
The evolving landscape of biomarkers for checkpoint inhibitor immunotherapy
Checkpoint inhibitor-based immunotherapies that target cytotoxic T lymphocyte antigen 4
(CTLA4) or the programmed cell death 1 (PD1) pathway have achieved impressive success …
(CTLA4) or the programmed cell death 1 (PD1) pathway have achieved impressive success …
Cold tumors: a therapeutic challenge for immunotherapy
P Bonaventura, T Shekarian, V Alcazer… - Frontiers in …, 2019 - frontiersin.org
Therapeutic monoclonal antibodies targeting immune checkpoints (ICPs) have changed the
treatment landscape of many tumors. However, response rate remains relatively low in most …
treatment landscape of many tumors. However, response rate remains relatively low in most …
Exploiting RIG-I-like receptor pathway for cancer immunotherapy
Y Jiang, H Zhang, J Wang, J Chen, Z Guo, Y Liu… - Journal of Hematology & …, 2023 - Springer
RIG-I-like receptors (RLRs) are intracellular pattern recognition receptors that detect viral or
bacterial infection and induce host innate immune responses. The RLRs family comprises …
bacterial infection and induce host innate immune responses. The RLRs family comprises …
The roles of DNA, RNA and histone methylation in ageing and cancer
Chromatin is a macromolecular complex predominantly comprising DNA, histone proteins
and RNA. The methylation of chromatin components is highly conserved as it helps …
and RNA. The methylation of chromatin components is highly conserved as it helps …
Ten things you should know about transposable elements
Transposable elements (TEs) are major components of eukaryotic genomes. However, the
extent of their impact on genome evolution, function, and disease remain a matter of intense …
extent of their impact on genome evolution, function, and disease remain a matter of intense …
Mechanisms of resistance to immune checkpoint inhibitors
Immune checkpoint inhibitors (ICI) targeting CTLA-4 and the PD-1/PD-L1 axis have shown
unprecedented clinical activity in several types of cancer and are rapidly transforming the …
unprecedented clinical activity in several types of cancer and are rapidly transforming the …
Loss of ADAR1 in tumours overcomes resistance to immune checkpoint blockade
Most patients with cancer either do not respond to immune checkpoint blockade or develop
resistance to it, often because of acquired mutations that impair antigen presentation. Here …
resistance to it, often because of acquired mutations that impair antigen presentation. Here …
The immune contexture in cancer prognosis and treatment
Immunotherapy is currently the most rapidly advancing area of clinical oncology, and
provides the unprecedented opportunity to effectively treat, and even cure, several …
provides the unprecedented opportunity to effectively treat, and even cure, several …