Cancer is a multifactorial, unpredictable chronic ailment with an anarchical, uncontrolled cell
proliferation and globally is one of the leading causes of mortality and morbidity owing to …

Chitosan is among the few polymers with high biocompatibility and low toxicity. In the area of
siRNA delivery, chitosan has been noted for its high buffer capacity in endosomal pH range …

Nanoparticle–hydrogel systems have recently emerged as a class of interesting hybrid
materials with immense potential for several biomedical applications. Remarkably, the …

А novel cationic chitosan derivative, N-[4-(N, N, N-trimethylammonium) benzyl] chitosan
chloride (TMAB-CS), with different degrees of substitution (DS) was synthesized by a …

Chitosan (CH) was N-alkylated via Schiff base formation and further reduced via sodium
borohydride. The reaction was carried out at room temperature, in a homogeneous aqueous …

At present, treating of triple negative breast cancer (TNBC) mainly depends on
chemotherapy with more toxic side effects, but the effect is limited and it is highly prone to …

We developed a nanovector with double targeting properties for efficiently delivering the
tumor suppressor gene RASSF1A specifically into hepatocellular carcinoma (HCC) cells by …

Non-viral gene delivery vectors are emerging as a safer alternative to viral vectors. Among
natural polymers, chitosan (Ch) is the most studied one, and low molecular weight Ch …

The nanoemulsion-based delivery systems have gained particular attention due to effective
encapsulation and protection of hydrophobic active compounds. However, several features …

There are sharply rising demands for pharmaceutical proteins, however shortcomings
associated with traditional protein production methods are obvious. Genetic engineering of …