Design and characterization of a fusion glycoprotein vaccine for Respiratory Syncytial Virus with improved stability

L Zhang, E Durr, JD Galli, S Cosmi, PJ Cejas, B Luo… - Vaccine, 2018 - Elsevier
Abstract Respiratory Syncytial Virus (RSV) infection is the leading cause of lower respiratory
tract infection in both young children and older adults. Currently, there is no licensed vaccine …

DNA immunization with plasmids encoding fusion and nucleocapsid proteins of bovine respiratory syncytial virus induces a strong cell-mediated immunity and …

M Boxus, M Tignon, S Roels, JF Toussaint… - Journal of …, 2007 - Am Soc Microbiol
Respiratory syncytial viruses (RSV) are one of the most important respiratory pathogens of
humans and cattle, and there is currently no safe and effective vaccine prophylaxis. In this …

Recent advances in the development of subunit-based RSV vaccines

N Jaberolansar, I Toth, PR Young… - Expert review of …, 2016 - Taylor & Francis
Respiratory syncytial virus (RSV) is a major cause of lower respiratory tract infections
causing pneumonia and bronchiolitis in infants. RSV also causes serious illness in elderly …

RSV N-nanorings fused to palivizumab-targeted neutralizing epitope as a nanoparticle RSV vaccine

PL Hervé, C Deloizy, D Descamps… - … , Biology and Medicine, 2017 - Elsevier
Respiratory syncytial virus (RSV) is the leading cause of acute respiratory infections in
children, yet no vaccine is available. The sole licensed preventive treatment against RSV is …

Immunopathology of RSV infection: prospects for developing vaccines without this complication

SD Littel‐van den Hurk, JW Mapletoft… - Reviews in medical …, 2007 - Wiley Online Library
Respiratory syncytial virus is the most important cause of lower respiratory tract infection in
infants and young children. RSV clinical disease varies from rhinitis and otitis media to …

[HTML][HTML] Contribution of cysteine residues in the extracellular domain of the F protein of human respiratory syncytial virus to its function

ND Day, PJ Branigan, C Liu, LL Gutshall, J Luo… - Virology Journal, 2006 - Springer
The mature F protein of all known isolates of human respiratory syncytial virus (HRSV)
contains fifteen absolutely conserved cysteine (C) residues that are highly conserved among …

[HTML][HTML] Structure-based design of head-only fusion glycoprotein immunogens for respiratory syncytial virus

JC Boyington, MG Joyce, M Sastry… - PloS one, 2016 - journals.plos.org
Respiratory syncytial virus (RSV) is a significant cause of severe respiratory illness
worldwide, particularly in infants, young children, and the elderly. Although no licensed …

Subcellular site of expression and route of vaccination influence pulmonary eosinophilia following respiratory syncytial virus challenge in BALB/c mice sensitized to …

GP Bembridge, R Garcia-Beato, JA López… - The Journal of …, 1998 - journals.aai.org
The attachment glycoprotein (G) of respiratory syncytial virus (RSV) is synthesized as two
mature forms: a membrane-anchored form and a smaller secreted form. Mutant cDNAs were …

Monoclonal antibody-resistant mutants selected with a respiratory syncytial virus-neutralizing human antibody fab fragment (Fab 19) define a unique epitope on the …

JE Crowe Jr, CY Firestone, R Crim, JA Beeler… - Virology, 1998 - Elsevier
A recombinant human antibody fragment, designated RSV Fab 19, efficiently neutralizes
respiratory syncytial virus (RSV). Here we report the results of our sequence analysis of …

Surveillance of clinical isolates of respiratory syncytial virus for palivizumab (Synagis)–resistant mutants

JP DeVincenzo, CB Hall, DW Kimberlin… - Journal of Infectious …, 2004 - academic.oup.com
Premature infants and those with chronic lung disease or congenital heart disease are at
high risk of severe respiratory syncytial virus (RSV) disease. Palivizumab (Synagis), a …