Semaphorins are extracellular signaling proteins that are essential for the development and
maintenance of many organs and tissues. The more than 20-member semaphorin protein …

Semaphorins are membrane-bound or diffusible factors that regulate key cellular functions
and are involved in cell–cell communication. Most of the effects of semaphorins are …

INTRODUCTION The thymus is the critical organ for T cell development and T cell receptor
(TCR) repertoire formation, which shapes the landscape of adaptive immunity. T cell …

Human stem cell-derived models of development and neurodegenerative diseases are
challenged by cellular immaturity in vitro. Microengineered organ-on-chip (or Organ-Chip) …

An outstanding characteristic of gliomas is their infiltration into brain parenchyma, a property
that impairs complete surgical resection; consequently, these tumors might recur, resulting in …

Semaphorins were originally identified as axon-guidance molecules that function during
neuronal development. However, cumulative evidence indicates that semaphorins also …

Human induced pluripotent stem cell-derived kidney organoids have potential for disease
modeling and to be developed into clinically transplantable auxiliary tissue. However, they …

Despite a large and multifaceted effort to understand the vast landscape of phenotypic data,
their current form inhibits productive data analysis. The lack of a community-wide …

The vasculature consists of an extensively branched network of blood and lymphatic vessels
that ensures the efficient circulation and thereby the supply of all tissues with oxygen and …

Angiogenesis and osteogenesis are coupled. However, the cellular and molecular
regulation of these processes remains to be further investigated. Both tissues have recently …