Why the evolution of vaccine resistance is less of a concern than the evolution of drug resistance

DA Kennedy, AF Read - Proceedings of the National …, 2018 - National Acad Sciences
Vaccines and antimicrobial drugs both impose strong selection for resistance. Yet only drug
resistance is a major challenge for 21st century medicine. Why is drug resistance ubiquitous …

Generation and evaluation of a recombinant Newcastle disease virus expressing the glycoprotein (G) of avian metapneumovirus subgroup C as a bivalent vaccine in …

H Hu, JP Roth, CN Estevez, L Zsak, B Liu, Q Yu - Vaccine, 2011 - Elsevier
Virulent strains of Newcastle disease virus (NDV) and avian metapneumovirus (aMPV) can
cause serious respiratory diseases in poultry. Vaccination combined with strict biosecurity …

What is new on molecular characteristics of Avian metapneumovirus strains circulating in Europe?

G Mescolini, C Lupini, G Franzo… - Transboundary and …, 2021 - Wiley Online Library
In the present study, one hundred and sixteen partial G gene sequences of Avian
metapneumovirus (aMPV) subtype B, obtained during routine diagnostics in different …

Rational design of human metapneumovirus live attenuated vaccine candidates by inhibiting viral mRNA cap methyltransferase

Y Zhang, Y Wei, X Zhang, H Cai, S Niewiesk… - Journal of virology, 2014 - Am Soc Microbiol
The paramyxoviruses human respiratory syncytial virus (hRSV), human metapneumovirus
(hMPV), and human parainfluenza virus type 3 (hPIV3) are responsible for the majority of …

Field avian metapneumovirus evolution avoiding vaccine induced immunity

E Catelli, C Lupini, M Cecchinato, E Ricchizzi, P Brown… - Vaccine, 2010 - Elsevier
Live avian metapneumovirus (AMPV) vaccines have largely brought turkey rhinotracheitis
(TRT) under control in Europe but unexplained outbreaks still occur. Italian AMPV …

[HTML][HTML] Phylogenetic and phylodynamic analyses of subtype-B metapneumovirus from chickens in Tunisia

J Lachheb, Z Bouslama, J Nsiri, C Badr, N Al Gallas… - Poultry Science, 2023 - Elsevier
ABSTRACT Swollen Head Syndrome (SHS) is an economically important viral disease of
chickens caused by avian metapneumovirus (aMPV). The virus comprises 6 different …

Methyltransferase-defective avian metapneumovirus vaccines provide complete protection against challenge with the homologous Colorado strain and the …

J Sun, Y Wei, A Rauf, Y Zhang, Y Ma, X Zhang… - Journal of …, 2014 - Am Soc Microbiol
Avian metapneumovirus (aMPV), also known as avian pneumovirus or turkey rhinotracheitis
virus, is the causative agent of turkey rhinotracheitis and is associated with swollen head …

[HTML][HTML] Evidence for the interaction of the human metapneumovirus G and F proteins during virus-like particle formation

LH Loo, MR Jumat, Y Fu, TC Ayi, PS Wong, NWS Tee… - Virology journal, 2013 - Springer
Background Human metapneumovirus (HMPV) is now a major cause of lower respiratory
infection in children. Although primary isolation of HMPV has been achieved in several …

[HTML][HTML] Protection by recombinant Newcastle disease viruses (NDV) expressing the glycoprotein (G) of avian metapneumovirus (aMPV) subtype A or B against …

Q Yu, JP Roth, H Hu, CN Estevez, W Zhao… - World Journal of …, 2013 - scirp.org
Avian metapneumovirus (aMPV) and Newcastle disease virus (NDV) are threatening avian
pathogens that can cause serious respiratory diseases in poultry worldwide. Vaccination …

Subpopulations in aMPV vaccines are unlikely to be the only cause of reversion to virulence

G Franzo, CJ Naylor, M Drigo, G Croville, MF Ducatez… - Vaccine, 2015 - Elsevier
Avian metapneumovirus (aMPV) infects respiratory and reproductive tracts of domestic
poultry, often involving secondary infections, and leads to serious economic losses in most …