We revisit our hypothesis that drug addiction can be viewed as the endpoint of a series of
transitions from initial voluntarily drug use to habitual, and ultimately compulsive drug use …

Drug addiction is a chronically relapsing disorder that has been characterized by (1)
compulsion to seek and take the drug,(2) loss of control in limiting intake, and (3) emergence …

We present a brief overview of the incentive sensitization theory of addiction. This posits that
addiction is caused primarily by drug-induced sensitization in the brain mesocorticolimbic …

Repeated exposure to drugs of abuse enhances the motor-stimulant response to these
drugs, a phenomenon termed behavioral sensitization. Animals that are extinguished from …

This review discusses the evidence for the hypothesis that the development of drug
addiction can be understood in terms of interactions between Pavlovian and instrumental …

We hypothesize that drug addiction can be viewed as the endpoint of a series of transitions
from initial voluntary drug use through the loss of control over this behaviour, such that it …

The motivation to seek out and consume rewards has evolutionarily been driven by the urge
to fulfill physiological needs. However in a modern society dominated more by plenty than …

Dysregulation of the brain emotional systems that mediate arousal and stress is a key
component of the pathophysiology of drug addiction. Drug addiction is a chronically …

Rationale Contemporary animal models of cocaine addiction focus on increasing the
amount of drug consumption to produce addiction-like behavior. However, another critical …

Several neuropsychological hypotheses have been formulated to explain the transition to
addiction, including hedonic allostasis, incentive salience, and the development of habits. A …