Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in ageing,
affecting around 46 million people worldwide but few treatments are currently available. The …

ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human
polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of …

Abstract Alzheimer's disease (AD), characterized by the β-amyloid protein (Aβ) deposition
and tau hyperphosphorylation, is the most common dementia with uncertain etiology. The …

Rosacea is significantly associated with dementia, particularly Alzheimer's disease (AD).
However, the common underlying molecular mechanism connecting these two diseases …

Nitric oxide, a ubiquitous molecule found throughout the natural world, is a key molecule
implicated in many central and benefic molecular pathways and has a well-established role …

Background A wide spectrum of changes occurs in the brain with age, from molecular to
morphological aspects, and inflammation accompanied by mitochondria dysfunction is one …

Alzheimer's disease (AD) is a neurodegenerative disorder that is characterised by the
presence of extracellular beta-amyloid fibrillary plaques and intraneuronal neurofibrillary tau …

Inflammation mediated by the innate immune system is a physiopathological response to
diverse detrimental circumstances such as microbe infections or tissular damage. The …

Alzheimer's disease (AD) is the most frequent cause of dementia worldwide. The etiology of
AD is partially explained by the deposition of β-amyloid in the brain. Despite extensive …

Abstract Type 2 diabetes (T2D) is implicated as a risk factor for Alzheimer's disease (AD), the
most common form of dementia. In this work, we investigated neuroinflammatory responses …