Efficacy and safety of lowering LDL cholesterol in older patients: a systematic review and meta-analysis of randomised controlled trials

B Gencer, NA Marston, KA Im, CP Cannon, P Sever… - The Lancet, 2020 - thelancet.com
Background The clinical benefit of LDL cholesterol lowering treatment in older patients
remains debated. We aimed to summarise the evidence of LDL cholesterol lowering …

Association of statin use in older people primary prevention group with risk of cardiovascular events and mortality: a systematic review and meta-analysis of …

K Awad, M Mohammed, MM Zaki, AI Abushouk… - BMC medicine, 2021 - Springer
Background Current evidence from randomized controlled trials on statins for primary
prevention of cardiovascular disease (CVD) in older people, especially those aged> 75 …

Statin discontinuation and cardiovascular events among older people in Denmark

W Thompson, L Morin, DE Jarbøl… - JAMA network …, 2021 - jamanetwork.com
Importance Statin use is common in older persons. Given uncertainties in ongoing benefit,
changes in health status, and shifting goals of care and preferences, statin discontinuation …

Lipids, lipid-modifying drug target genes and migraine: a Mendelian randomization study

Y Bi, Y Zhu, S Tang, Y Huang - The Journal of Headache and Pain, 2023 - Springer
Introduction Migraine, a prevalent headache disorder with unclear mechanisms and limited
treatments, may be influenced by dyslipidemia and genetic factors. Statins and emerging …

Atherogenic index of plasma is related to coronary atherosclerotic disease in elderly individuals: a cross-sectional study

H Huang, X Yu, L Li, G Shi, F Li, J Xiao, Z Yun… - Lipids in health and …, 2021 - Springer
Background Dyslipidaemia plays an important role in coronary atherosclerotic disease
(CAD). The relationship between the atherogenic index of plasma (AIP) and CAD in elderly …

Mortality in people with type 2 diabetes following SARS-CoV-2 infection: a population level analysis of potential risk factors

AH Heald, DA Jenkins, R Williams, M Sperrin… - Diabetes Therapy, 2022 - Springer
Introduction Research is ongoing to increase our understanding of how much a previous
diagnosis of type 2 diabetes mellitus (T2DM) affects someone's risk of becoming seriously …

Addressing disparities of care in non-ST-segment elevation myocardial infarction patients without standard modifiable risk factors: insights from a nationwide cohort …

SM Moledina, M Rashid, J Nolan… - European journal of …, 2022 - academic.oup.com
Aims The importance of standard modifiable cardiovascular risk factors (SMuRFs) in
preventing non-ST-segment elevation myocardial infarction (NSTEMI) is established …

Statins, mortality, and major adverse cardiovascular events among US veterans with chronic kidney disease

O Barayev, CE Hawley, H Wellman… - JAMA Network …, 2023 - jamanetwork.com
Importance There are limited data for the utility of statins for primary prevention of
atherosclerotic cardiovascular disease (ASCVD) and death in adults with chronic kidney …

LDL-C reduction with lipid-lowering therapy for primary prevention of major vascular events among older individuals

NW Andersson, G Corn, TL Dohlmann… - Journal of the American …, 2023 - jacc.org
Background Reducing low-density lipoprotein (LDL) cholesterol with lipid-lowering therapy
has consistently been shown to lower the risk of cardiovascular disease in primary …

Cholesterol paradox in older people with type 2 diabetes mellitus regardless of lipid-lowering drug use: a cross-sectional cohort study

TY Wang, WL Chang, CY Wei, CH Liu, RC Tzeng… - Nutrients, 2023 - mdpi.com
Lipid-lowering drugs (LLDs) have protective effects against coronary artery disease (CAD)
and cerebrovascular disease (CVD); however, a paradoxical association with cholesterol …