[HTML][HTML] The landscape of aging
Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …
[HTML][HTML] Mesenchymal stromal cells: putative microenvironmental modulators become cell therapy
M Krampera, K Le Blanc - Cell stem cell, 2021 - cell.com
An exceptional safety profile has been shown in a large number of cell therapy clinical trials
that use mesenchymal stromal cells (MSCs). However, reliable potency assays are still …
that use mesenchymal stromal cells (MSCs). However, reliable potency assays are still …
Stromal niche inflammation mediated by IL-1 signalling is a targetable driver of haematopoietic ageing
CA Mitchell, EV Verovskaya, FJ Calero-Nieto… - Nature cell …, 2023 - nature.com
Haematopoietic ageing is marked by a loss of regenerative capacity and skewed
differentiation from haematopoietic stem cells (HSCs), leading to impaired blood production …
differentiation from haematopoietic stem cells (HSCs), leading to impaired blood production …
Metastatic heterogeneity of breast cancer: Molecular mechanism and potential therapeutic targets
Breast cancer is one of the most common malignancies among women throughout the world
and is the major cause of most cancer-related deaths. Several explanations account for the …
and is the major cause of most cancer-related deaths. Several explanations account for the …
Combined single-cell and spatial transcriptomics reveal the molecular, cellular and spatial bone marrow niche organization
C Baccin, J Al-Sabah, L Velten, PM Helbling… - Nature cell …, 2020 - nature.com
The bone marrow constitutes the primary site for life-long blood production and skeletal
regeneration. However, its cellular and spatial organization remains controversial. Here, we …
regeneration. However, its cellular and spatial organization remains controversial. Here, we …
Cell competition in development, homeostasis and cancer
SM van Neerven, L Vermeulen - Nature Reviews Molecular Cell …, 2023 - nature.com
Organ development and homeostasis involve dynamic interactions between individual cells
that collectively regulate tissue architecture and function. To ensure the highest tissue …
that collectively regulate tissue architecture and function. To ensure the highest tissue …
The bone marrow microenvironment at single-cell resolution
The bone marrow microenvironment has a key role in regulating haematopoiesis, but its
molecular complexity and response to stress are incompletely understood. Here we map the …
molecular complexity and response to stress are incompletely understood. Here we map the …
Osteoimmunology: evolving concepts in bone–immune interactions in health and disease
M Tsukasaki, H Takayanagi - Nature Reviews Immunology, 2019 - nature.com
In terrestrial vertebrates, bone tissue constitutes the 'osteoimmune'system, which functions
as a locomotor organ and a mineral reservoir as well as a primary lymphoid organ where …
as a locomotor organ and a mineral reservoir as well as a primary lymphoid organ where …
[HTML][HTML] A cellular taxonomy of the bone marrow stroma in homeostasis and leukemia
N Baryawno, D Przybylski, MS Kowalczyk, Y Kfoury… - Cell, 2019 - cell.com
Stroma is a poorly defined non-parenchymal component of virtually every organ with key
roles in organ development, homeostasis, and repair. Studies of the bone marrow stroma …
roles in organ development, homeostasis, and repair. Studies of the bone marrow stroma …
Biological functions of mesenchymal stem cells and clinical implications
Mesenchymal stem cells (MSCs) are isolated from multiple biological tissues—adult bone
marrow and adipose tissues and neonatal tissues such as umbilical cord and placenta. In …
marrow and adipose tissues and neonatal tissues such as umbilical cord and placenta. In …