The role of macrophages in HIV-1 persistence and pathogenesis
Z Kruize, NA Kootstra - Frontiers in microbiology, 2019 - frontiersin.org
Current antiretroviral therapy (ART) effectively suppresses Human Immunodeficiency Virus
type 1 (HIV-1) in infected individuals. However, even long term ART does not eradicate HIV …
type 1 (HIV-1) in infected individuals. However, even long term ART does not eradicate HIV …
Transcriptional and posttranscriptional regulation of HIV-1 gene expression
J Karn, CM Stoltzfus - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
Control of HIV-1 gene expression depends on two viral regulatory proteins, Tat and Rev. Tat
stimulates transcription elongation by directing the cellular transcriptional elongation factor P …
stimulates transcription elongation by directing the cellular transcriptional elongation factor P …
Acetylation of histones and transcription-related factors
DE Sterner, SL Berger - Microbiology and molecular biology …, 2000 - Am Soc Microbiol
The state of chromatin (the packaging of DNA in eukaryotes) has long been recognized to
have major effects on levels of gene expression, and numerous chromatin-altering …
have major effects on levels of gene expression, and numerous chromatin-altering …
Cloning and characterization of a novel cellular protein, TDP-43, that binds to human immunodeficiency virus type 1 TAR DNA sequence motifs
Human immunodeficiency virus type 1 (HIV-1) gene expression is modulated by both viral
and cellular factors. A regulatory element in the HIV-1 long terminal repeat known as TAR …
and cellular factors. A regulatory element in the HIV-1 long terminal repeat known as TAR …
HIV-1 replication
EO Freed - Somatic cell and molecular genetics, 2001 - Springer
In general terms, the replication cycle of lentiviruses, including HIV-1, closely resembles that
of other retroviruses. 1 There are, however, a number of unique aspects of HIV replication; …
of other retroviruses. 1 There are, however, a number of unique aspects of HIV replication; …
Internalization of HIV-1 tat requires cell surface heparan sulfate proteoglycans
Tat, the transactivator protein of human immunodeficiency virus-1, has the unusual capacity
of being internalized by cells when present in the extracellular milieu. This property can be …
of being internalized by cells when present in the extracellular milieu. This property can be …
Presence of Tat and transactivation response element in spinal fluid despite antiretroviral therapy
Objective: The aim of this study was to measure the protein concentration and biological
activity of HIV-1 Tat in cerebrospinal fluid (CSF) of individuals on suppressive antiretroviral …
activity of HIV-1 Tat in cerebrospinal fluid (CSF) of individuals on suppressive antiretroviral …
Cell membrane lipid rafts mediate caveolar endocytosis of HIV-1 Tat fusion proteins
The transactivator protein of human immunodeficiency virus type 1 Tat has the unique
property of mediating the delivery of large protein cargoes into the cells when present in the …
property of mediating the delivery of large protein cargoes into the cells when present in the …
Normal microRNA maturation and germ-line stem cell maintenance requires Loquacious, a double-stranded RNA-binding domain protein
microRNAs (miRNAs) are single-stranded, 21-to 23-nucleotide cellular RNAs that control the
expression of cognate target genes. Primary miRNA (pri-miRNA) transcripts are transformed …
expression of cognate target genes. Primary miRNA (pri-miRNA) transcripts are transformed …
Conformation of the TAR RNA-arginine complex by NMR spectroscopy
JD Puglisi, R Tan, BJ Calnan, AD Frankel… - Science, 1992 - science.org
The messenger RNAs of human immunodeficiency virus-1 (HIV-1) have an RNA hairpin
structure, TAR, at their 5′ ends that contains a six-nucleotide loop and a three-nucleotide …
structure, TAR, at their 5′ ends that contains a six-nucleotide loop and a three-nucleotide …