Innate IRE1α-XBP1 activation by viral single-stranded RNA and its influence on lung cytokine production during SARS-CoV-2 pneumonia
JJ Fernández, C Mancebo, S Garcinuño, G March… - Genes & …, 2024 - nature.com
The utilization of host-cell machinery during SARS-CoV-2 infection can overwhelm the
protein-folding capacity of the endoplasmic reticulum and activate the unfolded protein …
protein-folding capacity of the endoplasmic reticulum and activate the unfolded protein …
The IRE1α-XBP1 arm of the unfolded protein response is a host factor activated in SARS-CoV-2 infection
SARS-CoV-2 infection can cause severe pneumonia, wherein exacerbated inflammation
plays a major role. This is reminiscent of the process commonly termed cytokine storm, a …
plays a major role. This is reminiscent of the process commonly termed cytokine storm, a …
[HTML][HTML] Non-canonical activation of IRE1α during Candida albicans infection enhances macrophage fungicidal activity
MJ McFadden, MB Reynolds, BC Michmerhuizen… - bioRxiv, 2023 - ncbi.nlm.nih.gov
While the canonical function of IRE1α is to detect misfolded proteins and activate the
unfolded protein response (UPR) to maintain cellular homeostasis, microbial pathogens can …
unfolded protein response (UPR) to maintain cellular homeostasis, microbial pathogens can …
Single-cell genotype-phenotype mapping identifies therapeutic vulnerabilities in VEXAS syndrome
Somatic evolution leads to the emergence of clonal diversity across tissues with broad
implications for human health. A striking example of somatic evolution is the VEXAS …
implications for human health. A striking example of somatic evolution is the VEXAS …
[PDF][PDF] POSTDOCTORAL TRAINING
CUO de Guatemala - 2022 - usasp.org
Participation as Member of Evaluation Committees: July 2005 Member of the evaluation
committee of the doctoral thesis: Efectos supraespinales de la N-ciclopentil adenosina …
committee of the doctoral thesis: Efectos supraespinales de la N-ciclopentil adenosina …
Supplemental figure legends
A Brichkina - gut.bmj.com
A Genomic data on DYRK1B from the TCGA data set (www. cbioportal. org). B Kaplan-Meier
plot depicting DYRK1B-associated overall survival of PDAC patients (n= 146 patients, TCGA …
plot depicting DYRK1B-associated overall survival of PDAC patients (n= 146 patients, TCGA …