Glycoconjugates: synthesis, functional studies, and therapeutic developments
Glycoconjugates are major constituents of mammalian cells that are formed via covalent
conjugation of carbohydrates to other biomolecules like proteins and lipids and often …
conjugation of carbohydrates to other biomolecules like proteins and lipids and often …
[HTML][HTML] The tumor microenvironment: a milieu hindering and obstructing antitumor immune responses
A Labani-Motlagh, M Ashja-Mahdavi… - Frontiers in …, 2020 - frontiersin.org
The success of cancer immunotherapy relies on the knowledge of the tumor
microenvironment and the immune evasion mechanisms in which the tumor, stroma, and …
microenvironment and the immune evasion mechanisms in which the tumor, stroma, and …
The tumor microenvironment innately modulates cancer progression
DC Hinshaw, LA Shevde - Cancer research, 2019 - AACR
Cancer development and progression occurs in concert with alterations in the surrounding
stroma. Cancer cells can functionally sculpt their microenvironment through the secretion of …
stroma. Cancer cells can functionally sculpt their microenvironment through the secretion of …
[HTML][HTML] An immunostimulatory glycolipid that blocks SARS-CoV-2, RSV, and influenza infections in vivo
Prophylactic vaccines for SARS-CoV-2 have lowered the incidence of severe COVID-19, but
emergence of viral variants that are antigenically distinct from the vaccine strains are of …
emergence of viral variants that are antigenically distinct from the vaccine strains are of …
[HTML][HTML] Unconventional T cell targets for cancer immunotherapy
DI Godfrey, J Le Nours, DM Andrews, AP Uldrich… - Immunity, 2018 - cell.com
Most studies on the immunotherapeutic potential of T cells have focused on CD8 and CD4 T
cells that recognize peptide antigens (Ag) presented by polymorphic major histocompatibility …
cells that recognize peptide antigens (Ag) presented by polymorphic major histocompatibility …
Targeting natural killer cells and natural killer T cells in cancer
Natural killer (NK) cells and natural killer T (NKT) cells are subsets of lymphocytes that share
some phenotypical and functional similarities. Both cell types can rapidly respond to the …
some phenotypical and functional similarities. Both cell types can rapidly respond to the …
[HTML][HTML] The role of natural killer T cells in cancer—a phenotypical and functional approach
D Krijgsman, M Hokland, PJK Kuppen - Frontiers in immunology, 2018 - frontiersin.org
Natural killer T (NKT) cells are a subset of CD1d-restricted T cells at the interface between
the innate and adaptive immune system. NKT cells can be subdivided into functional …
the innate and adaptive immune system. NKT cells can be subdivided into functional …
[HTML][HTML] The current landscape of NKT cell immunotherapy and the hills ahead
Simple Summary Natural killer T (NKT) cells are a subset of lipid-reactive T cells that
enhance anti-tumor immunity. While preclinical studies have shown NKT cell …
enhance anti-tumor immunity. While preclinical studies have shown NKT cell …
Regulatory B cells prevent and reverse allergic airway inflammation via FoxP3-positive T regulatory cells in a murine model
S Amu, SP Saunders, M Kronenberg… - Journal of Allergy and …, 2010 - Elsevier
BACKGROUND: Parasitic helminth infections of humans have been shown to suppress the
immune response to allergens. Experimentally, infection of mice with the helminth …
immune response to allergens. Experimentally, infection of mice with the helminth …
Inflammation and immune surveillance in cancer
Chronic inflammation is a risk factor for tumor development. However, understanding the
effect of the immune system on tumor development has only been significantly advanced …
effect of the immune system on tumor development has only been significantly advanced …