Transporters influence the disposition of chemicals within the body by participating in
absorption, distribution, and elimination. Transporters of the solute carrier family (SLC) …

P-glycoprotein, the most extensively studied ATP-binding cassette (ABC) transporter,
functions as a biological barrier by extruding toxins and xenobiotics out of cells. In vitro and …

One of the major problems related with anticancer chemotherapy is resistance against
anticancer drugs. The ATP-binding cassette (ABC) transporters are a family of transporter …

ATP Binding Cassette (ABC) transporters form a special family of membrane proteins,
characterized by homologous ATP-binding, and large, multispanning transmembrane …

Relative plasma, brain and cerebrospinal fluid (CSF) exposures and unbound fractions in
plasma and brain were examined for 18 proprietary compounds in rats. The relationship …

Pluronicв block copolymers are recognized pharmaceutical excipients listed in the US and
British Pharmacopoeia. The incorporation of drugs into Pluronic micelles results in …

A variety of drug transporters expressed in the body control the fate of drugs by affecting
absorption, distribution, and elimination processes. In the small intestine, transporters …

Rivaroxaban, an oral, direct factor Xa inhibitor, has a dual mode of elimination in humans,
with two-thirds metabolized by the liver and one-third renally excreted unchanged. P …

ATP-binding cassette (ABC) transporters, P-glycoprotein (P-gp, ABCB1) and ABCG2, are
membrane proteins that couple the energy derived from ATP hydrolysis to efflux many …

Drug efflux transporters can influence the absorption, tissue distribution and elimination of
many therapeutic agents. Modulation of drug efflux transporter activity is being explored as a …