This review is focused on methods for detecting small molecules and, in particular, the
characterisation of their interaction with natural proteins (eg receptors, ion channels) …

The nucleotides diadenosine triphosphate (Ap3A) and diadenosine tetraphosphate (Ap4A)
are formed in prokaryotic and eukaryotic cells. Since their concentrations increase …

Nucleotides modified at the terminal phosphate position have been proven to be interesting
entities to study the activity of a variety of different protein classes. In this chapter, we present …

Abstract Poly (ADP‐ribos) ylation (PARylation) is a major posttranslational modification and
signaling event in most eukaryotes. Fundamental processes like DNA repair and …

Adenosine triphosphate (ATP) analogues labelled with two dyes suitable for undergoing
Förster Resonance Energy Transfer (FRET) have the potential to be valuable tools to …

Esters and anhydrides of phosphoric acid are essential in biology. It is very difficult to identify
processes in life that do not involve these modifications and their transformation at some …

Many enzymes use ATP in signal-transducing processes or as an energy source. New
fluorogenic ATP analogues signal ATP consumption by ubiquitin-like protein-activating …

Cancer is a leading cause of death worldwide. Functional inactivation of tumor suppressor
proteins, mainly by mutations in the corresponding genes, is a key event in cancer …

Several nucleotide-specific phosphohydrolases can cleave P–F bonds in substrate
analogues containing a fluorophosphate moiety to release fluoride ions. In this work, by …

Adenosine triphosphate (ATP) probes modified with fluorescence dyes that change their
fluorescence properties upon cleavage are an interesting tool for monitoring enzymatic ATP …