The phospatidylinositol-3 kinase (PI3K) pathway is a crucial intracellular signaling pathway
which is mutated or amplified in a wide variety of cancers including breast, gastric, ovarian …

Simple Summary Early-stage and castration-sensitive prostate cancer (PCa) growth is solely
mediated by androgen signaling pathways. AR signaling inhibitors (ARSIs) have …

Loss of the tumor suppressor phosphatase and tensin homologue deleted on chromosome
10 (PTEN), which negatively regulates the PI3K–AKT–mTOR pathway, is strongly linked to …

Prostate cancer (PCa) is the most common malignancy in men of middle and older age. The
standard treatment strategy for PCa ranges from active surveillance in low-grade, localized …

Background Prostate cancer is one of leading causes of cancer death among men
worldwide. Androgen deprivation therapy is a central part of the prostate cancer treatment …

Cancer is one of the leading causes of death in humans. Despite the progress in cancer
treatment, and an increase in the effectiveness of diagnostic methods, cancer is still highly …

Castration-resistant prostate cancer, or CRPC, is an aggressive stage of prostate cancer
(PCa) in which PCa cells invade nearby or other parts of the body. When a patient with PCa …

In recent years, many therapeutic advances have been made in the management of
castration-resistant prostate cancer, with the development and approval of many new drugs …

Prostate cancer (CaP) is the second leading cause of cancer-related deaths in western men.
Because androgens drive CaP by activating the androgen receptor (AR), blocking AR's …

Androgens act through the androgen receptor (AR) and are critical regulators of prostate
differentiation and function, as well as prostate cancer (PCa) growth and survival. The …