[HTML][HTML] Mechanosensation of tight junctions depends on ZO-1 phase separation and flow
C Schwayer, S Shamipour, K Pranjic-Ferscha… - Cell, 2019 - cell.com
Cell-cell junctions respond to mechanical forces by changing their organization and
function. To gain insight into the mechanochemical basis underlying junction …
function. To gain insight into the mechanochemical basis underlying junction …
A mechanically active heterotypic E-cadherin/N-cadherin adhesion enables fibroblasts to drive cancer cell invasion
Cancer-associated fibroblasts (CAFs) promote tumour invasion and metastasis. We show
that CAFs exert a physical force on cancer cells that enables their collective invasion. Force …
that CAFs exert a physical force on cancer cells that enables their collective invasion. Force …
[HTML][HTML] Vascularized and complex organ buds from diverse tissues via mesenchymal cell-driven condensation
Transplantation of in-vitro-generated organ buds is a promising approach toward
regenerating functional and vascularized organs. Though it has been recently shown in the …
regenerating functional and vascularized organs. Though it has been recently shown in the …
Transduction of mechanical and cytoskeletal cues by YAP and TAZ
The physical and mechanical properties of the cellular microenvironment regulate cell
shape and can strongly influence cell fate. How mechanical cues are sensed and …
shape and can strongly influence cell fate. How mechanical cues are sensed and …
[HTML][HTML] Forces in tissue morphogenesis and patterning
CP Heisenberg, Y Bellaïche - Cell, 2013 - cell.com
During development, mechanical forces cause changes in size, shape, number, position,
and gene expression of cells. They are therefore integral to any morphogenetic processes …
and gene expression of cells. They are therefore integral to any morphogenetic processes …
[HTML][HTML] Mechanical force-driven adherens junction remodeling and epithelial dynamics
D Pinheiro, Y Bellaiche - Developmental cell, 2018 - cell.com
During epithelial tissue development, repair, and homeostasis, adherens junctions (AJs)
ensure intercellular adhesion and tissue integrity while allowing for cell and tissue …
ensure intercellular adhesion and tissue integrity while allowing for cell and tissue …
Tensegrity, cellular biophysics, and the mechanics of living systems
The recent convergence between physics and biology has led many physicists to enter the
fields of cell and developmental biology. One of the most exciting areas of interest has been …
fields of cell and developmental biology. One of the most exciting areas of interest has been …
Dynamic molecular processes mediate cellular mechanotransduction
Cellular responses to mechanical forces are crucial in embryonic development and adult
physiology, and are involved in numerous diseases, including atherosclerosis …
physiology, and are involved in numerous diseases, including atherosclerosis …
[HTML][HTML] Fluid shear stress on endothelial cells modulates mechanical tension across VE-cadherin and PECAM-1
Fluid shear stress (FSS) from blood flow acting on the endothelium critically regulates
vascular morphogenesis, blood pressure, and atherosclerosis [1]. FSS applied to …
vascular morphogenesis, blood pressure, and atherosclerosis [1]. FSS applied to …
[HTML][HTML] Cell migration
Cell migration is fundamental to establishing and maintaining the proper organization of
multicellular organisms. Morphogenesis can be viewed as a consequence, in part, of cell …
multicellular organisms. Morphogenesis can be viewed as a consequence, in part, of cell …