Head and neck cancer (HNC) is malignant, genetically complex and difficult to treat and is
the sixth most frequent cancer, with tobacco, alcohol and human papillomavirus being major …

Due to the complexity of multifactorial diseases, single-target drugs do not always exhibit
satisfactory efficacy. Recently, increasing evidence indicates that simultaneous modulation …

Multitargeting compounds comprising activity on more than a single biological target have
gained remarkable relevance in drug discovery owing to the complexity of multifactorial …

Human DNA topoisomerase II is an important target in anticancer therapy. Despite the
clinical success of drugs that target topoisomerase II, the development of resistant cancer …

Multi-target drugs have raised considerable interest in the last decade owing to their
advantages in the treatment of complex diseases and health conditions linked to drug …

Polypharmacology is a concept where a molecule can interact with two or more targets
simultaneously. It offers many advantages as compared to the conventional single-targeting …

The receptor tyrosine kinase c-MET and its ligand, hepatocyte growth factor (HGF), regulate
multiple cellular processes that stimulate cell proliferation, invasion and angiogenesis. This …

Natural chemical compounds have been widely investigated for their programmed necrosis
causing characteristics. One of the conventional methods for screening such compounds is …

Toll-like receptors (TLRs) are key components of the innate immune system and serve as a
crucial link between innate and acquired immunity. In addition to immune function, TLRs are …

In recent years, tyrosine kinases (TKs) have been recognized as central players and
regulators of cancer cell proliferation, apoptosis, and angiogenesis, and are therefore …