Glucocorticoids (GCs) are steroids secreted by the adrenal cortex under the hypothalamic-
pituitary-adrenal axis control, one of the major neuro-endocrine systems of the organism …

The aging process is associated with loss of muscle mass and strength and decline in
physical functioning. The term sarcopenia is primarily defined as low level of muscle mass …

Duchenne muscular dystrophy (DMD) is a severe, progressive, and ultimately fatal disease
of skeletal muscle wasting, respiratory insufficiency, and cardiomyopathy. The identification …

Glucocorticoids (GCs) exert key metabolic influences on skeletal muscle. GCs increase
protein degradation and decrease protein synthesis. The released amino acids are …

The superfamily of transforming growth factor-β (TGF-β) cytokines has been shown to have
profound effects on cellular proliferation, differentiation, and growth. Recently, there have …

During the course of life, muscle mass undergoes many changes in terms of quantity and
quality. Skeletal muscle is a dynamic tissue able to hypertrophy or atrophy according to …

Skeletal muscle atrophy in individuals with advanced chronic obstructive pulmonary disease
(COPD) is associated with diminished quality of life, increased health resource use, and …

Background Although the satellite cell (SC) is a key regulator of muscle growth during
development and muscle adaptation following exercise, the regulation of human muscle SC …

Sarcopenia is characterized by reduced skeletal muscle mass and strength in older
individuals. It is one of the leading cause of physical limitation in older adults, and …

Prolonged excess of glucocorticoids (GCs) has adverse systemic effects leading to
significant morbidities and an increase in mortality. Metabolic alterations associated with the …