The repurposing of non-peptide neurokinin-1 receptor antagonists as antitumor drugs: An urgent challenge for aprepitant

R Coveñas, FD Rodríguez, P Robinson… - International journal of …, 2023 - mdpi.com
The substance P (SP)/neurokinin-1 receptor (NK-1R) system is involved in cancer
progression. NK-1R, activated by SP, promotes tumor cell proliferation and migration …

Role of Cannabinoids in Oral Cancer

B Cretu, A Zamfir, S Bucurica, AE Scheau… - International Journal of …, 2024 - mdpi.com
Cannabinoids have incited scientific interest in different conditions, including malignancy,
due to increased exposure to cannabis. Furthermore, cannabinoids are increasingly used to …

The interaction mechanism of candidone with calf thymus DNA: A multi-spectroscopic and MD simulation study

MF Dehkordi, S Farhadian, F Hashemi-Shahraki… - International Journal of …, 2023 - Elsevier
In this investigation, the effects of candidone on the structure and conformation of DNA were
evaluated by spectroscopic methods, molecular dynamics simulation, and molecular …

Investigating the effect of pH on the interaction of cypermethrin with human serum albumin: Insights from spectroscopic and molecular dynamics simulation studies

MA Mohammadi, B Shareghi, S Farhadian… - International Journal of …, 2024 - Elsevier
To efficiently combat the negative consequences of the utilization of pesticides and
hazardous substances with biomolecules, it is crucial to comprehend the features of the …

Combined effect of plasma-activated water and topotecan in glioblastoma cells

B Pinheiro Lopes, L O'Neill, P Bourke, D Boehm - Cancers, 2023 - mdpi.com
Simple Summary New forms of cancer treatment are needed to target resistant cancers or
reduce severe side effects associated with some treatments. Cold Atmospheric Plasma …

Interaction between the antioxidant compound safranal and α-chymotrypsin in spectroscopic fields and molecular modeling approaches

S Zohreh Vahedi, S Farhadian, B Shareghi… - Journal of …, 2024 - Taylor & Francis
Among various herbal plants, saffron has been the subject of study in various medical and
food fields. Among the compounds of saffron, safranal is one of them. Safranal is a …

Effect of folic acid‐linked chitosan‐coated PLGA‐based curcumin nanoparticles on the redox system of glioblastoma cancer cells

N Ghoreyshi, A Ghahremanloo, H Javid… - Phytochemical …, 2023 - Wiley Online Library
Objectives Oxidative stress is one of the carcinogenic mechanisms underlying the
development of glioblastoma multiforme (GBM), a highly aggressive brain tumor type …

The Role of Silymarin in Mitigating Inflammation and Cognitive Impairment Induced by Ovariectomy in Wistar Rats

R Moalefshahri, H Javid, F Gheybi… - Mediators of …, 2023 - Wiley Online Library
Background. Silymarin, a polyphenolic flavonoid found in milk thistle, has been used to treat
liver and brain injuries in humans and animals. The study aims to investigate the protective …

Glioblastoma, an opportunity T cell trafficking could bring for the treatment

M Karimi-Shahri, M Khorramdel, S Zarei… - Molecular Biology …, 2022 - Springer
Purpose Infiltrating into the vital structure of the brain, located in the inaccessible anatomical
region, and having molecular heterogeneity, glioblastoma (GBM)–with no doubt–is one of …

Shake It Up Baby Now: The Changing Focus on TWIST1 and Epithelial to Mesenchymal Transition in Cancer and Other Diseases

D Mirjat, M Kashif, CM Roberts - International Journal of Molecular …, 2023 - mdpi.com
TWIST1 is a transcription factor that is necessary for healthy neural crest migration,
mesoderm development, and gastrulation. It functions as a key regulator of epithelial-to …