Since its first clinical description (on his son) by William James West (1793–1848) in 1841,
and the definition of the classical triad of (1) infantile spasms;(2) hypsarrhythmia, and (3) …

Children with infantile spasms are likely to have a poor outcome. Outcome measures for
infantile spasms include primary response to treatment, relapse of spasms, neurological …

Objectives The manuscript serves as an update on the current management practices for
infantile spasm syndrome (ISS). It includes a detailed summary of the level of current …

Objective To compare the therapeutic effectiveness of oral corticosteroids with that of
adrenocorticotrophic hormone for infantile spasms. Methods PubMed, Embase, Scopus, and …

Aim To compare the efficacy and safety of prednisolone/prednisone and adrenocorticotropic
hormone (ACTH) in the treatment of infantile spasms using a meta‐analysis of randomized …

Background Hormonal therapy is the treatment of choice in most patients with infantile
spasms, but the optimal way to provide this therapy is unclear. Intramuscular …

Background This article explores the role of initial treatment on control of spasms and other
epilepsies at four years in children previously treated for West syndrome. Methods The Sri …

Infantile spasms (IS or epileptic spasms during infancy) were first described by Dr. William
James West (aka West syndrome) in his own son in 1841. While rare by definition (occurring …

Introduction Infantile spasm (IS) is an epileptic syndrome with typical onset within the first 2
years of life. This condition might be caused by several etiologies. IS is associated with …

Background There is ongoing debate regarding the comparative effectiveness of
adrenocorticotropic hormone and prednisolone in the treatment of infantile spasms. With a …