The microenvironment is increasingly recognized to have key roles in cancer, and
biomaterials provide a means to engineer microenvironments both in vitro and in vivo to …

Abstract 3D in vitro models have been used in cancer research as a compromise between 2-
dimensional cultures of isolated cancer cells and the manufactured complexity of xenografts …

Altered microarchitecture of collagen type I is a hallmark of wound healing and cancer that is
commonly attributed to myofibroblasts. However, it remains unknown which effect collagen …

Cancer remains one of the leading causes of death, albeit enormous efforts to cure the
disease. To overcome the major challenges in cancer therapy, we need to have a better …

Type I collagen is a favorable substrate for cell adhesion and growth and is remodelable by
many tissue cells; these characteristics make it an attractive material for the study of dynamic …

Cells cultured within a three-dimensional (3D) in vitro environment have the ability to
acquire phenotypes and respond to stimuli analogous to in vivo biological systems. This …

Cellular function and behavior are affected by the partial pressure of O2, or oxygen tension,
in the microenvironment. The level of oxygenation is important, as it is a balance of oxygen …

Angiogenesis, the outgrowth of blood vessels, is crucial in development, disease and
regeneration. Studying angiogenesis in vitro remains challenging because the capillary …

Advances in microengineering technologies have enabled a variety of insights into
biomedical sciences that would not have been possible with conventional techniques …

Glioblastoma multiforme contains a subpopulation of cancer stem–like cells (CSC) believed
to underlie tumorigenesis and therapeutic resistance. Recent studies have localized CSCs …