Pharmacokinetics (PK) is the study of the absorption, distribution, metabolism, and excretion
(ADME) processes of a drug. Understanding PK properties is essential for drug development …

Drug metabolism and pharmacokinetics (DMPK) is an important branch of pharmaceutical
sciences. The nature of ADME (absorption, distribution, metabolism, excretion) and PK …

Ferroptosis is widely involved in degenerative diseases in various tissues including kidney,
liver and brain, and is a targetable vulnerability in multiple primary and therapy-resistant …

ChEMBL is an open large-scale bioactivity database (https://www. ebi. ac. uk/chembl),
previously described in the 2012 and 2014 Nucleic Acids Research Database Issues. Since …

Background Enzyme-mediated biotransformation of pharmacological agents is a crucial step
in xenobiotic detoxification and drug disposition. Herein, we investigated the metabolism …

Background: In January 2020, the US FDA published two final guidelines, one entitled “In
vitro Drug Interaction Studies-Cytochrome P450 Enzyme-and Transporter-Mediated Drug …

Significance: Ferroptosis is featured by the accumulation of polyunsaturated-lipid
peroxidation on cellular membranes in an iron-dependent manner. Ferroptosis has been …

Carboxylesterase (CES) 1 is the most abundant drug-metabolizing enzyme in human livers,
comprising approximately 1% of the entire liver proteome. CES1 is responsible for 80 …

Drug–drug interactions (DDIs) caused by the co‐administration of multiple drugs are major
safety concerns in the clinic. Several drugs have been withdrawn from the market due to …

Current pharmacotherapy options of drug-induced liver injury (DILI) remain under
discussion and are now evaluated in this analysis. Needless to say, the use of the offending …