Histone deacetylases, as a new class of anticancer targets, could maintain homeostasis by
catalyzing histone deacetylation and play important roles in regulating the expression of …

Abstract The US Food and Drug Administration has approved a total of 37 new drugs in
2022, which are composed of 20 chemical entities and 17 biologics. In particular, 20 …

Recently emerging generative AI models enable us to produce a vast number of compounds
for potential applications. While they can provide novel molecular structures, the synthetic …

Following nearly two decades of development, significant advancements have been
achieved in PROTAC technology. As of the end of 2022, more than 20 drugs have entered …

The microtubule system plays an important role in the mitosis and growth of eukaryotic cells,
and it is considered as an appealing and highly successful molecular target for cancer …

Highlights•Metabolic procedures of a nucleoside anticancer drug are summarized.•
Anticancer properties of newly synthesized nucleoside analogs are introduced.•Synthetic …

In this work, a series of novel arylamide derivatives containing piperazine moiety were
designed and synthesised as tubulin polymerisation inhibitors. Among 25 target …

In this work, we employed a ring-opening strategy to develop a series of novel N-benzyl
arylamide derivatives as tubulin polymerization inhibitors. Notably, 13n (MY-1388) exhibited …

In this work, a series of novel coumarin-based derivatives were designed and synthesized
as tubulin polymerization inhibitors targeting the colchicine binding site, and their …

In this study, twenty-one novel 2, 4-diaminopyrimidine cinnamyl derivatives as inhibitors
targeting FAK were designed and synthesized based on the structure of TAE-226, and the …