[HTML][HTML] Cryopreservation of bioflavonoid-rich plant sources and bioflavonoid-microcapsules: emerging technologies for preserving bioactivity and enhancing …
Bioflavonoids are natural polyphenolic secondary metabolites that are medicinal. These
compounds possess antitumor, cardioprotective, anti-inflammatory, antimicrobial, antiviral …
compounds possess antitumor, cardioprotective, anti-inflammatory, antimicrobial, antiviral …
[HTML][HTML] Anticancer potential of natural chalcones: in vitro and in vivo evidence
R Michalkova, L Mirossay, M Kello… - International Journal of …, 2023 - mdpi.com
There is no doubt that significant progress has been made in tumor therapy in the past
decades. However, the discovery of new molecules with potential antitumor properties still …
decades. However, the discovery of new molecules with potential antitumor properties still …
[HTML][HTML] Design, synthesis, X-ray crystal structures, anticancer, DNA binding, and molecular modelling studies of pyrazole–pyrazoline hybrid derivatives
We have designed and synthesized three pyrazole analogs (4, 5a, 5b), pyrazole-based
chalcones (6a–6d) and (8a–8h), and N-formyl/acetyl 1, 3, 5-trisubstituted pyrazoline analogs …
chalcones (6a–6d) and (8a–8h), and N-formyl/acetyl 1, 3, 5-trisubstituted pyrazoline analogs …
[HTML][HTML] Hydroxy chalcones and analogs with chemopreventive properties
The aim of this review is to highlight the chemopreventive properties of hydroxy-substituted
natural and synthetic chalcones along with a number of their analogs. These products …
natural and synthetic chalcones along with a number of their analogs. These products …
Synthetic non-toxic anti-biofilm agents as a strategy in combating bacterial resistance
RM Hassan, MS Abd El-Maksoud, IAY Ghannam… - European Journal of …, 2023 - Elsevier
The tremendous increase in the bacterial resistance to the available antibiotics is a serious
problem for the treatment of various infections. Biofilm formation in bacteria significantly …
problem for the treatment of various infections. Biofilm formation in bacteria significantly …
Nano-curcumin formulations for targeted therapy of colorectal cancer
Colorectal cancer (CRC) is the third most common cause of cancer death in men and
women. Chemotherapeutic drugs such as 5-fluorouracil (5-FU), irinotecan, and oxaliplatin …
women. Chemotherapeutic drugs such as 5-fluorouracil (5-FU), irinotecan, and oxaliplatin …
Flavonoids as omnipotent candidates for cancer management
The development of the cancer is a complex process as it proliferates, alters the signaling
pathways, and ultimately reduced the patient's survival. The altered cellular events and …
pathways, and ultimately reduced the patient's survival. The altered cellular events and …
[HTML][HTML] Design, synthesis and evaluation of the 2′-hydroxy-3′-iodo-5′-nitrochalcones for cytotoxicity (MCF-7 & A549) and potential to inhibit tyrosine kinase …
MJ Mphahlele, GK More, JK Nkoana… - Journal of Molecular …, 2024 - Elsevier
A series of the 2‑hydroxy-3-iodo-5-nitrochalcones 3a–n was synthesized and characterized
spectroscopically (FT-IR, ESI-MS, 1 HNMR, and 13 CNMR) complemented with single …
spectroscopically (FT-IR, ESI-MS, 1 HNMR, and 13 CNMR) complemented with single …
Cytotoxic Effect of New (E)‐2‐Cyano‐N‐(tetrahydrobenzo[b]thiophen‐2‐yl)acrylamide Derivatives: Down‐Regulation of RBL2 and STAT2 and Triggering of DNA …
NS Ibrahim, FM Sroor, KF Mahrous… - …, 2023 - Wiley Online Library
A novel series of 2‐cyano‐N‐(tetrahydrobenzo [b] thiophen‐2‐yl) acrylamide derivatives
were synthesized and their structures were confirmed using several spectral tools. All …
were synthesized and their structures were confirmed using several spectral tools. All …
Chalcone-based imidazo[2,1-b]thiazole derivatives: synthesis, crystal structure, potent anticancer activity, and computational studies
In this work, two novel chalcone-based imidazothiazole derivatives ITC-1 and ITC-2 were
synthesized and characterized by 1H NMR, 13C NMR and high-resolution mass …
synthesized and characterized by 1H NMR, 13C NMR and high-resolution mass …