Targeting the p53 signaling pathway in cancers: Molecular mechanisms and clinical studies

J Shen, Q Wang, Y Mao, W Gao, S Duan - MedComm, 2023 - Wiley Online Library
Tumor suppressor p53 can transcriptionally activate downstream genes in response to
stress, and then regulate the cell cycle, DNA repair, metabolism, angiogenesis, apoptosis …

Novel approaches in the systemic management of high-risk prostate cancer

MA Gómez-Aparicio, F López-Campos… - Clinical Genitourinary …, 2023 - Elsevier
Locally advanced prostate cancer comprises approximately 20% of new prostate cancer
diagnoses. For these patients, international guidelines recommend treatment with …

Biochemical recurrence surrogacy for clinical outcomes after radiotherapy for adenocarcinoma of the prostate

S Roy, T Romero, JM Michalski, FY Feng… - Journal of Clinical …, 2023 - ascopubs.org
PURPOSE The surrogacy of biochemical recurrence (BCR) for overall survival (OS) in
localized prostate cancer remains controversial. Herein, we evaluate the surrogacy of BCR …

Salvage irreversible electroporation for radio‐recurrent prostate cancer–the prospective FIRE trial

A Blazevski, B Geboers, MJ Scheltema… - BJU …, 2023 - Wiley Online Library
Objectives To prospectively assess the safety, functional‐and oncological‐outcomes of
irreversible electroporation (IRE) as salvage therapy for radio‐recurrent focal prostate …

Ablative radiotherapy improves survival but does not cure autochthonous mouse models of prostate and colorectal cancer

DR Schmidt, IMT Gramatikov, A Sheen… - Communications …, 2023 - nature.com
Background Genetically engineered mouse models (GEMMs) of cancer are powerful tools to
study mechanisms of disease progression and therapy response, yet little is known about …

LUNAR: a randomized Phase 2 study of 177Lutetium‐PSMA Neoadjuvant to Ablative Radiotherapy for Oligorecurrent Prostate Cancer (clinical trial protocol)

TM Ma, J Czernin, C Felix, R Alano… - BJU …, 2023 - Wiley Online Library
Objective To assess the efficacy of 177Lu‐PNT2002, a novel radiolabelled small molecule
that binds with high affinity to prostate‐specific membrane antigen (PSMA), in combination …

Prostate-specific membrane antigen radioguided surgery with negative histopathology: an in-depth analysis

D Koehler, S Trappe, F Shenas, A Karimzadeh… - European Journal of …, 2024 - Springer
Purpose To identify reasons for negative histopathology of specimens from prostate-specific
membrane antigen (PSMA) radioguided surgery (PSMA-RGS) in recurrent prostate cancer …

Longitudinal changes and predictive value of multiparametric mri features for prostate cancer patients treated with MRI-guided lattice extreme ablative dose (LEAD) …

A Algohary, M Alhusseini, AL Breto, D Kwon, IR Xu… - Cancers, 2022 - mdpi.com
Simple Summary In this study, we investigated the longitudinal changes and predictive
value of multiparametric MRI (mpMRI) features of prostate cancer patients receiving Lattice …

Jorge clinical study: 10-year outcomes of risk-adapted radiotherapy defined by multiparametric MRI for prostate cancer

V Duque-Santana, A Diaz-Gavela, M Recio… - World Journal of …, 2023 - Springer
Purpose To analyze the 10-year biochemical relapse-free survival (BRFS), locoregional
relapse-free survival (LRFS), metastasis-free survival (MFS), and overall survival (OS) in …

Patterns of Failure in Men With Radiorecurrent Prostate Cancer: A Post Hoc Analysis of 3 Prospective Gallium 68 Prostate-Specific Membrane Antigen Positron …

CP Smith, M Xiang, WR Armstrong, NG Nickols… - International Journal of …, 2023 - Elsevier
Results In total, 168 patients who underwent PSMA PET/CT for suspected radiorecurrent
PCa were eligible, 40 of whom were excluded for having initial cN1 disease, missing …