Targeting the p53 signaling pathway in cancers: Molecular mechanisms and clinical studies
J Shen, Q Wang, Y Mao, W Gao, S Duan - MedComm, 2023 - Wiley Online Library
Tumor suppressor p53 can transcriptionally activate downstream genes in response to
stress, and then regulate the cell cycle, DNA repair, metabolism, angiogenesis, apoptosis …
stress, and then regulate the cell cycle, DNA repair, metabolism, angiogenesis, apoptosis …
Novel approaches in the systemic management of high-risk prostate cancer
MA Gómez-Aparicio, F López-Campos… - Clinical Genitourinary …, 2023 - Elsevier
Locally advanced prostate cancer comprises approximately 20% of new prostate cancer
diagnoses. For these patients, international guidelines recommend treatment with …
diagnoses. For these patients, international guidelines recommend treatment with …
Biochemical recurrence surrogacy for clinical outcomes after radiotherapy for adenocarcinoma of the prostate
PURPOSE The surrogacy of biochemical recurrence (BCR) for overall survival (OS) in
localized prostate cancer remains controversial. Herein, we evaluate the surrogacy of BCR …
localized prostate cancer remains controversial. Herein, we evaluate the surrogacy of BCR …
Salvage irreversible electroporation for radio‐recurrent prostate cancer–the prospective FIRE trial
A Blazevski, B Geboers, MJ Scheltema… - BJU …, 2023 - Wiley Online Library
Objectives To prospectively assess the safety, functional‐and oncological‐outcomes of
irreversible electroporation (IRE) as salvage therapy for radio‐recurrent focal prostate …
irreversible electroporation (IRE) as salvage therapy for radio‐recurrent focal prostate …
Ablative radiotherapy improves survival but does not cure autochthonous mouse models of prostate and colorectal cancer
DR Schmidt, IMT Gramatikov, A Sheen… - Communications …, 2023 - nature.com
Background Genetically engineered mouse models (GEMMs) of cancer are powerful tools to
study mechanisms of disease progression and therapy response, yet little is known about …
study mechanisms of disease progression and therapy response, yet little is known about …
LUNAR: a randomized Phase 2 study of 177Lutetium‐PSMA Neoadjuvant to Ablative Radiotherapy for Oligorecurrent Prostate Cancer (clinical trial protocol)
TM Ma, J Czernin, C Felix, R Alano… - BJU …, 2023 - Wiley Online Library
Objective To assess the efficacy of 177Lu‐PNT2002, a novel radiolabelled small molecule
that binds with high affinity to prostate‐specific membrane antigen (PSMA), in combination …
that binds with high affinity to prostate‐specific membrane antigen (PSMA), in combination …
Prostate-specific membrane antigen radioguided surgery with negative histopathology: an in-depth analysis
D Koehler, S Trappe, F Shenas, A Karimzadeh… - European Journal of …, 2024 - Springer
Purpose To identify reasons for negative histopathology of specimens from prostate-specific
membrane antigen (PSMA) radioguided surgery (PSMA-RGS) in recurrent prostate cancer …
membrane antigen (PSMA) radioguided surgery (PSMA-RGS) in recurrent prostate cancer …
Longitudinal changes and predictive value of multiparametric mri features for prostate cancer patients treated with MRI-guided lattice extreme ablative dose (LEAD) …
Simple Summary In this study, we investigated the longitudinal changes and predictive
value of multiparametric MRI (mpMRI) features of prostate cancer patients receiving Lattice …
value of multiparametric MRI (mpMRI) features of prostate cancer patients receiving Lattice …
Jorge clinical study: 10-year outcomes of risk-adapted radiotherapy defined by multiparametric MRI for prostate cancer
V Duque-Santana, A Diaz-Gavela, M Recio… - World Journal of …, 2023 - Springer
Purpose To analyze the 10-year biochemical relapse-free survival (BRFS), locoregional
relapse-free survival (LRFS), metastasis-free survival (MFS), and overall survival (OS) in …
relapse-free survival (LRFS), metastasis-free survival (MFS), and overall survival (OS) in …
Patterns of Failure in Men With Radiorecurrent Prostate Cancer: A Post Hoc Analysis of 3 Prospective Gallium 68 Prostate-Specific Membrane Antigen Positron …
CP Smith, M Xiang, WR Armstrong, NG Nickols… - International Journal of …, 2023 - Elsevier
Results In total, 168 patients who underwent PSMA PET/CT for suspected radiorecurrent
PCa were eligible, 40 of whom were excluded for having initial cN1 disease, missing …
PCa were eligible, 40 of whom were excluded for having initial cN1 disease, missing …