Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need

MC Field, D Horn, AH Fairlamb… - Nature Reviews …, 2017 - nature.com
The WHO recognizes human African trypanosomiasis, Chagas disease and the
leishmaniases as neglected tropical diseases. These diseases are caused by parasitic …

[HTML][HTML] Leishmania infections: Molecular targets and diagnosis

M Akhoundi, T Downing, J Votýpka, K Kuhls… - Molecular aspects of …, 2017 - Elsevier
Progress in the diagnosis of leishmaniases depends on the development of effective
methods and the discovery of suitable biomarkers. We propose firstly an update …

[PDF][PDF] The potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases-part II

TJ Schmidt, SA Khalid, AJ Romanha, TMA Alves… - 2012 - lavierebelle.org
Infections with protozoan parasites are a major cause of disease and mortality in many
tropical countries of the world. Diseases caused by species of the genera Trypanosoma …

[HTML][HTML] Visceral leishmaniasis treatment: what do we have, what do we need and how to deliver it?

LH Freitas-Junior, E Chatelain, HA Kim… - International Journal for …, 2012 - Elsevier
Leishmaniasis is one of the most neglected tropical disease in terms of drug discovery and
development. Most antileishmanial drugs are highly toxic, present resistance issues or …

[HTML][HTML] Analysis of the mathematical model of cutaneous leishmaniasis disease

M Sinan, KJ Ansari, A Kanwal, K Shah… - Alexandria Engineering …, 2023 - Elsevier
Mathematical models are powerful tools to study various real-world problems from different
perspectives. This branch has been given much more popularity over the last several …

Animal models for the study of leishmaniasis immunology

EN Loría-Cervera, FJ Andrade-Narváez - Revista do Instituto de …, 2014 - SciELO Brasil
Leishmaniasis remains a major public health problem worldwide and is classified as
Category I by the TDR/WHO, mainly due to the absence of control. Many experimental …

A parasite rescue and transformation assay for antileishmanial screening against intracellular Leishmania donovani amastigotes in THP1 human acute monocytic …

SK Jain, R Sahu, LA Walker, BL Tekwani - JoVE (Journal of Visualized …, 2012 - jove.com
Leishmaniasis is one of the world's most neglected diseases, largely affecting the poorest of
the poor, mainly in developing countries. Over 350 million people are considered at risk of …

Comparison of a high-throughput high-content intracellular Leishmania donovani assay with an axenic amastigote assay

M De Rycker, I Hallyburton, J Thomas… - Antimicrobial agents …, 2013 - Am Soc Microbiol
Visceral leishmaniasis is a neglected tropical disease with significant health impact. The
current treatments are poor, and there is an urgent need to develop new drugs. Primary …

From ocean to medicine: Pharmaceutical applications of metabolites from marine bacteria

JD Santos, I Vitorino, F Reyes, F Vicente, OM Lage - Antibiotics, 2020 - mdpi.com
Oceans cover seventy percent of the planet's surface and besides being an immense
reservoir of biological life, they serve as vital sources for human sustenance, tourism …

[HTML][HTML] Route map for the discovery and pre-clinical development of new drugs and treatments for cutaneous leishmaniasis

D Caridha, B Vesely, K van Bocxlaer, B Arana… - International Journal for …, 2019 - Elsevier
Although there have been significant advances in the treatment of visceral leishmaniasis
(VL) and several novel compounds are currently in pre-clinical and clinical development for …