Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need
The WHO recognizes human African trypanosomiasis, Chagas disease and the
leishmaniases as neglected tropical diseases. These diseases are caused by parasitic …
leishmaniases as neglected tropical diseases. These diseases are caused by parasitic …
[HTML][HTML] Leishmania infections: Molecular targets and diagnosis
Progress in the diagnosis of leishmaniases depends on the development of effective
methods and the discovery of suitable biomarkers. We propose firstly an update …
methods and the discovery of suitable biomarkers. We propose firstly an update …
[PDF][PDF] The potential of secondary metabolites from plants as drugs or leads against protozoan neglected diseases-part II
TJ Schmidt, SA Khalid, AJ Romanha, TMA Alves… - 2012 - lavierebelle.org
Infections with protozoan parasites are a major cause of disease and mortality in many
tropical countries of the world. Diseases caused by species of the genera Trypanosoma …
tropical countries of the world. Diseases caused by species of the genera Trypanosoma …
[HTML][HTML] Visceral leishmaniasis treatment: what do we have, what do we need and how to deliver it?
LH Freitas-Junior, E Chatelain, HA Kim… - International Journal for …, 2012 - Elsevier
Leishmaniasis is one of the most neglected tropical disease in terms of drug discovery and
development. Most antileishmanial drugs are highly toxic, present resistance issues or …
development. Most antileishmanial drugs are highly toxic, present resistance issues or …
[HTML][HTML] Analysis of the mathematical model of cutaneous leishmaniasis disease
Mathematical models are powerful tools to study various real-world problems from different
perspectives. This branch has been given much more popularity over the last several …
perspectives. This branch has been given much more popularity over the last several …
Animal models for the study of leishmaniasis immunology
EN Loría-Cervera, FJ Andrade-Narváez - Revista do Instituto de …, 2014 - SciELO Brasil
Leishmaniasis remains a major public health problem worldwide and is classified as
Category I by the TDR/WHO, mainly due to the absence of control. Many experimental …
Category I by the TDR/WHO, mainly due to the absence of control. Many experimental …
A parasite rescue and transformation assay for antileishmanial screening against intracellular Leishmania donovani amastigotes in THP1 human acute monocytic …
SK Jain, R Sahu, LA Walker, BL Tekwani - JoVE (Journal of Visualized …, 2012 - jove.com
Leishmaniasis is one of the world's most neglected diseases, largely affecting the poorest of
the poor, mainly in developing countries. Over 350 million people are considered at risk of …
the poor, mainly in developing countries. Over 350 million people are considered at risk of …
Comparison of a high-throughput high-content intracellular Leishmania donovani assay with an axenic amastigote assay
M De Rycker, I Hallyburton, J Thomas… - Antimicrobial agents …, 2013 - Am Soc Microbiol
Visceral leishmaniasis is a neglected tropical disease with significant health impact. The
current treatments are poor, and there is an urgent need to develop new drugs. Primary …
current treatments are poor, and there is an urgent need to develop new drugs. Primary …
From ocean to medicine: Pharmaceutical applications of metabolites from marine bacteria
Oceans cover seventy percent of the planet's surface and besides being an immense
reservoir of biological life, they serve as vital sources for human sustenance, tourism …
reservoir of biological life, they serve as vital sources for human sustenance, tourism …
[HTML][HTML] Route map for the discovery and pre-clinical development of new drugs and treatments for cutaneous leishmaniasis
D Caridha, B Vesely, K van Bocxlaer, B Arana… - International Journal for …, 2019 - Elsevier
Although there have been significant advances in the treatment of visceral leishmaniasis
(VL) and several novel compounds are currently in pre-clinical and clinical development for …
(VL) and several novel compounds are currently in pre-clinical and clinical development for …