Proto-oncogenes and tumor suppressors critically control cell-fate decisions like cell
survival, adaptation and death. These processes are regulated by Ca2+ signals arising from …

Background To determine whether chlorambucil treatment benefits patients with indolent
chronic lymphocytic leukemia (CLL), we conducted two randomized trials in 1535 patients …

The management of chronic lymphocytic leukemia (CLL) is currently undergoing a profound
change. First, several new drugs have been approved (fludarabine, bendamustine and two …

BACKGROUND: The randomized trials that evaluate the timing and intensity of initial
chemotherapy for chronic lymphocytic leukemia (CLL) have, in general, been too small to …

BACKGROUND In recent years, much attention has been paid to the possible efficacy of
intensive chemotherapy in the treatment of advanced, progressive B‐cell chronic …

In an ongoing study, families with two or more living cases of B-CLL in first-degree relatives
have been recruited through physician and self-referral. Since 1967, 28 kindreds with 73 …

Recurrent spontaneous abortion (RSA) is a major health concern for women, affecting one
in every 100 couples wishing to have children (Stephenson 1996). It has been estimated …

Chronic lymphocytic leukemia (CLL) is the most common lymphoproliferative disorder in the
West accounting for about 30% of leukemias, but about 2–4% in India. There is no large …

The treatment of chronic lymphocytic leukemia (CLL) currently relies on the use of chemo-
immunotherapy, Bruton's tyrosine kinase inhibitors, or BCL2 inhibitors alone or combined …

Purpose A prospective, multicenter, open-label, phase II clinical trial to assess oral
fludarabine phosphate treatment in terms of safety, efficacy, and quality of life. Reference to …