The potential of endurance exercise-derived exosomes to treat metabolic diseases

A Safdar, A Saleem, MA Tarnopolsky - Nature Reviews Endocrinology, 2016 - nature.com
Endurance exercise-mediated multisystemic adaptations are known to mitigate metabolism-
related disorders such as obesity and type 2 diabetes mellitus (T2DM). However, the …

Molecular mechanisms of cardiac remodeling and regeneration in physical exercise

D Schüttler, S Clauss, LT Weckbach, S Brunner - Cells, 2019 - mdpi.com
Regular physical activity with aerobic and muscle-strengthening training protects against the
occurrence and progression of cardiovascular disease and can improve cardiac function in …

Physical exercise and epigenetic modifications in skeletal muscle

M Widmann, AM Nieß, B Munz - Sports medicine, 2019 - Springer
Physical activity and sports play major roles in the overall health status of humans. It is well
known that regular exercise helps to lower the risk for a broad variety of health problems …

Exosomes as mediators of the systemic adaptations to endurance exercise

A Safdar, MA Tarnopolsky - Cold Spring …, 2018 - perspectivesinmedicine.cshlp.org
Habitual endurance exercise training is associated with multisystemic metabolic adaptations
that lower the risk of inactivity-associated disorders such as obesity and type 2 diabetes …

[HTML][HTML] Biogenesis and function of extracellular vesicles in pathophysiological processes of skeletal muscle atrophy

W Wang, M Li, Z Chen, L Xu, M Chang, K Wang… - Biochemical …, 2022 - Elsevier
Pathophysiological changes of skeletal muscle occur in a variety of chronic diseases,
leading to muscle atrophy and dysfunction, which greatly affect the quality of life. Despite …

Noncoding RNAs in cardiovascular disease: current knowledge, tools and technologies for investigation, and future directions: a scientific statement from the american …

S Das, R Shah, S Dimmeler, JE Freedman… - Circulation: Genomic …, 2020 - Am Heart Assoc
Background: The discovery that much of the non–protein-coding genome is transcribed and
plays a diverse functional role in fundamental cellular processes has led to an explosion in …

Understanding key mechanisms of exercise-induced cardiac protection to mitigate disease: current knowledge and emerging concepts

BC Bernardo, JYY Ooi, KL Weeks… - Physiological …, 2018 - journals.physiology.org
The benefits of exercise on the heart are well recognized, and clinical studies have
demonstrated that exercise is an intervention that can improve cardiac function in heart …

Normalization strategies differently affect circulating miRNA profile associated with the training status

M Faraldi, M Gomarasca, V Sansoni, S Perego… - Scientific Reports, 2019 - nature.com
MicroRNAs are fine regulators of the whole-body adaptive response but their use as
biomarkers is limited by the lack of standardized pre-and post-analytical procedures. This …

[HTML][HTML] MicroRNAs as important regulators of exercise adaptation

GJJ Silva, A Bye, H El Azzouzi, U Wisløff - Progress in cardiovascular …, 2017 - Elsevier
A significant body of evidence supports the protective role of exercise training (ET) in
cardiovascular diseases, skeletal muscle dystrophies, several types of cancer, Alzheimer …

Aerobic exercise training promotes physiological cardiac remodeling involving a set of microRNAs

T Fernandes, VG Baraúna… - American Journal …, 2015 - journals.physiology.org
Left ventricular (LV) hypertrophy is an important physiological compensatory mechanism in
response to chronic increase in hemodynamic overload. There are two different forms of LV …