Taxol®, which is also known as paclitaxel, is a chemotherapeutic agent widely used to treat
different cancers. Since the discovery of its antitumoral activity, Taxol® has been used to …

Over the past decade, covalent kinase inhibitors (CKI) have seen a resurgence in drug
discovery. Covalency affords a unique set of advantages as well as challenges relative to …

Pancreatic endocrine tumors (PETs) have long fascinated clinicians and investigators
despite their relative rarity. Their clinical presentation varies depending on whether the …

Apples are among the most popular fruits in the world. They are rich in phenolic compounds,
pectin, sugar, macro-and microelements. Applying different extraction techniques it is …

Deregulation of many kinases is directly linked to cancer development and the tyrosine
kinase family is one of the most important targets in current cancer therapy regimens. In this …

Background Triple-negative breast cancers (TNBC) neither express hormone receptors, nor
overexpress HER2. They are associated with poor prognosis, as defined by low five-year …

The monoclonal antibodies panitumumab and cetuximab that target the epidermal growth
factor receptor (EGFR) have expanded the range of treatment options for metastatic …

Co-delivery multiple drugs using nanocarriers has been recognized as a promising strategy
for cancer treatment to enhance therapeutic efficacy. In this study, a pH sensitive …

Anticancer drug nephrotoxicity is an important and increasing adverse drug event that limits
the efficacy of cancer treatment. The kidney is an important elimination pathway for many …

Epidermal growth factor receptor (EGFR, also known as ErbB-1 or HER-1) is a membrane
bound protein that has been associated with a variety of solid tumors and the control of cell …