Mode of action of nintedanib in the treatment of idiopathic pulmonary fibrosis
L Wollin, E Wex, A Pautsch, G Schnapp… - European …, 2015 - Eur Respiratory Soc
Idiopathic pulmonary fibrosis (IPF) is a progressive and ultimately fatal disease
characterised by fibrosis of the lung parenchyma and loss of lung function. Although the …
characterised by fibrosis of the lung parenchyma and loss of lung function. Although the …
Pathophysiological consequences of VEGF-induced vascular permeability
SM Weis, DA Cheresh - Nature, 2005 - nature.com
Although vascular endothelial growth factor (VEGF) induces angiogenesis, it also disrupts
vascular barrier function in diseased tissues. Accordingly, VEGF expression in cancer and …
vascular barrier function in diseased tissues. Accordingly, VEGF expression in cancer and …
[HTML][HTML] Mechanosensing and mechanoregulation of endothelial cell functions
Vascular endothelial cells (ECs) form a semiselective barrier for macromolecules and cell
elements regulated by dynamic interactions between cytoskeletal elements and cell …
elements regulated by dynamic interactions between cytoskeletal elements and cell …
[HTML][HTML] VEGF and FGF-2: Promising targets for the treatment of respiratory disorders
AP Laddha, YA Kulkarni - Respiratory medicine, 2019 - Elsevier
The endothelial cells play a crucial role in the progression of angiogenesis, which causes
cell re-modulation, proliferation, adhesion, migration, invasion and survival. Angiogenic …
cell re-modulation, proliferation, adhesion, migration, invasion and survival. Angiogenic …
Vascular endothelial growth factor in the lung
NF Voelkel, RW Vandivier… - American Journal of …, 2006 - journals.physiology.org
Vascular endothelial growth factor (VEGF) is a pluripotent growth and permeability factor
that has a broad impact on endothelial cell function. The lung tissue is very rich in this …
that has a broad impact on endothelial cell function. The lung tissue is very rich in this …
A pathophysiologic approach to biomarkers in acute respiratory distress syndrome
R Blondonnet, JM Constantin, V Sapin… - Disease …, 2016 - Wiley Online Library
Acute respiratory distress syndrome (ARDS) is an acute‐onset hypoxic condition with
radiographic bilateral lung infiltration. It is characterized by an acute exudative phase …
radiographic bilateral lung infiltration. It is characterized by an acute exudative phase …
The immunological balance between host and parasite in malaria
K Deroost, TT Pham, G Opdenakker… - FEMS microbiology …, 2016 - academic.oup.com
Coevolution of humans and malaria parasites has generated an intricate balance between
the immune system of the host and virulence factors of the parasite, equilibrating maximal …
the immune system of the host and virulence factors of the parasite, equilibrating maximal …
Cyclic stretch, reactive oxygen species, and vascular remodeling
KG Birukov - Antioxidants & redox signaling, 2009 - liebertpub.com
Blood vessels respond to changes in mechanical load from circulating blood in the form of
shear stress and mechanical strain as the result of heart propulsions by changes in …
shear stress and mechanical strain as the result of heart propulsions by changes in …
[HTML][HTML] Redox signaling in acute pancreatitis
S Pérez, J Pereda, L Sabater, J Sastre - Redox biology, 2015 - Elsevier
Acute pancreatitis is an inflammatory process of the pancreatic gland that eventually may
lead to a severe systemic inflammatory response. A key event in pancreatic damage is the …
lead to a severe systemic inflammatory response. A key event in pancreatic damage is the …
Hyperoxia-induced bronchopulmonary dysplasia: better models for better therapies
K Giusto, H Wanczyk, T Jensen… - Disease Models & …, 2021 - journals.biologists.com
Bronchopulmonary dysplasia (BPD) is a chronic lung disease caused by exposure to high
levels of oxygen (hyperoxia) and is the most common complication that affects preterm …
levels of oxygen (hyperoxia) and is the most common complication that affects preterm …