Reciprocal regulation of microRNA-1 and insulin-like growth factor-1 signal transduction cascade in cardiac and skeletal muscle in physiological and pathological …
L Elia, R Contu, M Quintavalle, F Varrone, C Chimenti… - Circulation, 2009 - Am Heart Assoc
Background—MicroRNAs (miRNAs/miRs) are small conserved RNA molecules of 22
nucleotides that negatively modulate gene expression primarily through base paring to the …
nucleotides that negatively modulate gene expression primarily through base paring to the …
[HTML][HTML] Protein kinase cascades in the regulation of cardiac hypertrophy
GW Dorn, T Force - The Journal of clinical investigation, 2005 - Am Soc Clin Investig
In broad terms, there are 3 types of cardiac hypertrophy: normal growth, growth induced by
physical conditioning (ie, physiologic hypertrophy), and growth induced by pathologic …
physical conditioning (ie, physiologic hypertrophy), and growth induced by pathologic …
Differences between pathological and physiological cardiac hypertrophy: novel therapeutic strategies to treat heart failure.
JR McMullen, GL Jennings - Clinical & Experimental …, 2007 - search.ebscohost.com
In general, cardiac hypertrophy (an increase in heart mass) is a poor prognostic sign.
Cardiac enlargement is a characteristic of most forms of heart failure. Cardiac hypertrophy …
Cardiac enlargement is a characteristic of most forms of heart failure. Cardiac hypertrophy …
[HTML][HTML] T cell costimulation blockade blunts pressure overload-induced heart failure
Heart failure (HF) is a leading cause of mortality. Inflammation is implicated in HF, yet clinical
trials targeting pro-inflammatory cytokines in HF were unsuccessful, possibly due to …
trials targeting pro-inflammatory cytokines in HF were unsuccessful, possibly due to …
Activation or inactivation of cardiac Akt/mTOR signaling diverges physiological from pathological hypertrophy
Cardiomyocyte hypertrophy differs according to the stress exerted on the myocardium. While
pressure overload‐induced cardiomyocyte hypertrophy is associated with depressed …
pressure overload‐induced cardiomyocyte hypertrophy is associated with depressed …
The role of phosphoinositide-3 kinase and PTEN in cardiovascular physiology and disease
Phosphoinositide-3 kinases (PI3Ks) are a family of evolutionary conserved lipid kinases that
mediate many cellular responses in both physiologic and pathophysiologic states. Class I …
mediate many cellular responses in both physiologic and pathophysiologic states. Class I …
[HTML][HTML] From sirtuin biology to human diseases: an update
C Sebastián, FK Satterstrom, MC Haigis… - Journal of Biological …, 2012 - ASBMB
Originally rising to notoriety for their role in the regulation of aging, sirtuins are a family of
NAD+-dependent enzymes that have been connected to a steadily growing set of biological …
NAD+-dependent enzymes that have been connected to a steadily growing set of biological …
Pregnancy as a cardiac stress model
E Chung, LA Leinwand - Cardiovascular research, 2014 - academic.oup.com
Cardiac hypertrophy occurs during pregnancy as a consequence of both volume overload
and hormonal changes. Both pregnancy-and exercise-induced cardiac hypertrophy are …
and hormonal changes. Both pregnancy-and exercise-induced cardiac hypertrophy are …
Proinflammatory cytokines in heart failure: double-edged swords
Increased circulating and intracardiac levels of proinflammatory cytokines have been
associated with chronic heart failure. Following an initial insult, the increased production of …
associated with chronic heart failure. Following an initial insult, the increased production of …
Akt1/protein kinase B enhances transcriptional reprogramming of fibroblasts to functional cardiomyocytes
Conversion of fibroblasts to functional cardiomyocytes represents a potential approach for
restoring cardiac function after myocardial injury, but the technique thus far has been slow …
restoring cardiac function after myocardial injury, but the technique thus far has been slow …