α-lipoic acid (ALA, thioctic acid) is an organosulfur component produced from plants,
animals, and humans. It has various properties, among them great antioxidant potential and …

Chemotherapy-induced peripheral neuropathic pain (CIPNP)—a severe adverse effect
observed in up to 80% of patients during treatment with antineoplastic drugs—limits the …

Mitochondrial function and specifically its implication in cellular redox/oxidative balance is
fundamental in controlling the life and death of cells, and has been implicated in a wide …

The aim of this article is to describe the current and potential clinical translation of
pharmacological inhibitors of poly (ADP-ribose) polymerase (PARP) for the therapy of …

Age-related alterations in human gut microbiota composition have been thoroughly
described, but a detailed functional description of the intestinal bacterial coding capacity is …

Loss of function in mitochondria, the key organelle responsible for cellular energy
production, can result in the excess fatigue and other symptoms that are common complaints …

Mycobacterium tuberculosis, the cause of Tuberculosis (TB), infects one third of the world's
population and causes substantial mortality worldwide. In its shortest format, treatment of TB …

Abstract Paraquat (PQ, 1, 1'-dimethyl-4-4'-bipyridinium dichloride) is a highly toxic
quaternary ammonium herbicide widely used in agriculture, it exerts its toxic effects mainly …

Microglia-mediated neuroinflammation is one of the most significant features in a variety of
central nervous system (CNS) disorders such as traumatic brain injury, stroke, and many …

Diabetes mellitus is an endocrinological disorder arising from insulin deficiency or due to
ineffectiveness of the insulin produced by the body. This results in high blood glucose and …