Astrocytic p75NTR expression provoked by ischemic stroke exacerbates the blood–brain barrier disruption

X Qin, J Wang, S Chen, G Liu, C Wu, Q Lv, X He, X Bai… - Glia, 2022 - Wiley Online Library
The disruption of the blood–brain barrier (BBB) plays a critical role in the pathology of
ischemic stroke. p75 neurotrophin receptor (p75NTR) contributes to the disruption of the …

Repetitive transcranial magnetic stimulation for stroke rehabilitation: insights into the molecular and cellular mechanisms of neuroinflammation

R Sheng, C Chen, H Chen, P Yu - Frontiers in Immunology, 2023 - frontiersin.org
Stroke is a leading cause of mortality and disability worldwide, with most survivors reporting
dysfunctions of motor, sensation, deglutition, cognition, emotion, and speech, etc. Repetitive …

Blood-brain barrier dysfunction in CNS disorders and putative therapeutic targets: an overview

SR Archie, A Al Shoyaib, L Cucullo - Pharmaceutics, 2021 - mdpi.com
The blood-brain barrier (BBB) is a fundamental component of the central nervous system
(CNS). Its functional and structural integrity is vital to maintain the homeostasis of the brain …

Astroglial Cells: Emerging Therapeutic Targets in the Management of Traumatic Brain Injury

W Czyżewski, M Mazurek, L Sakwa, M Szymoniuk… - Cells, 2024 - mdpi.com
Traumatic Brain Injury (TBI) represents a significant health concern, necessitating advanced
therapeutic interventions. This detailed review explores the critical roles of astrocytes, key …

Non-excitatory amino acids, melatonin, and free radicals: examining the role in stroke and aging

VJ Carretero, E Ramos, P Segura-Chama… - Antioxidants, 2023 - mdpi.com
The aim of this review is to explore the relationship between melatonin, free radicals, and
non-excitatory amino acids, and their role in stroke and aging. Melatonin has garnered …

Photobiomodulation treatment inhibits neurotoxic astrocytic polarization and protects neurons in in vitro and in vivo stroke models

Y Feng, L Yang, X Ma, Z Huang, X Zong… - Neurochemistry …, 2023 - Elsevier
The beneficial effects of photobiomodulation (PBM) on function recovery after stroke have
been well-established, while its molecular and cellular mechanisms remain to be elucidated …

Autophagy-mediated circHIPK2 promotes lipopolysaccharide-induced astrocytic inflammation via SIGMAR1

R Huang, L Cai, X Ma, K Shen - International Immunopharmacology, 2023 - Elsevier
Circular RNAs (circRNAs) are a subclass of noncoding RNAs and widely involve in the
occurrence of multiple human diseases. It is an urgent task to clarify circRNA upstream …

[HTML][HTML] Astrocyte-derived extracellular vesicles for ischemic stroke: therapeutic potential and prospective

X Wang, A Li, H Fan, Y Li, N Yang, Y Tang - Aging and Disease, 2024 - ncbi.nlm.nih.gov
Stroke is a leading cause of death and disability in the world. Astrocytes are special glial
cells within the central nervous system and play important roles in mediating …

Dysfunction of the neurovascular unit in ischemic stroke: highlights on microRNAs and exosomes as potential biomarkers and therapy

T Forró, Z Bajkó, A Bălașa, R Bălașa - International journal of molecular …, 2021 - mdpi.com
Ischemic stroke is a damaging cerebral vascular disease associated with high disability and
mortality rates worldwide. In spite of the continuous development of new diagnostic and …

Updated understanding of the glial-vascular unit in central nervous system disorders

D Yao, R Zhang, M Xie, F Ding, M Wang, W Wang - Neuroscience bulletin, 2023 - Springer
The concept of the glial-vascular unit (GVU) was raised recently to emphasize the close
associations between brain cells and cerebral vessels, and their coordinated reactions to …