Pericytes play critical roles in the maintenance of brain vascular homeostasis. However, very
little is currently known about how pericytes regulate ischemic stroke-induced brain injury …

Neuronal loss (death) occurs selectively in vulnerable brain regions after ischemic insults.
Astrogliosis is accompanied by neuronal death. It can change the molecular expression and …

Even though astrocytes have been widely reported to support several brain functions,
studies have emerged that they exert deleterious effects on the brain after ischemia and …

Glial activation with the production of pro‐inflammatory mediators is a major driver of
disease progression in neurological processes ranging from acute traumatic injury to …

S100B is an astrocytic cytokine that has been shown to be involved in several
neurodegenerative diseases. We used an astrocytoma cell line (U373 MG) silenced for …

Exposure to hypoxic-ischemic (HI) insults in newborns can predispose them to severe
neurological sequela. The mechanisms underlying HI-related brain injury have not been …

As the second-leading cause of death, stroke faces several challenges in terms of treatment
because of the limited therapeutic interventions available. Previous studies primarily …

Candidate drugs targeting the central nervous system (CNS) demonstrate extremely low
clinical success rates, with more than 98% of potential treatments being discontinued due to …

Preserving stroke penumbra by targeting lipid signalling - Beatriz Achón Buil, Ruslan Rust,
2023 Skip to main content Intended for healthcare professionals Sage Journals Home Search …

Exposure to atmospheric particulate matter (PM) has been found to accelerate the onset of
neurological disorders via the induction of detrimental neuroinflammatory responses. To …