Low-intensity focused ultrasound stimulation promotes stroke recovery via astrocytic HMGB1 and CAMK2N1 in mice

L Qi, C Wang, L Deng, JJ Pan, Q Suo, S Wu… - Stroke and Vascular …, 2024 - svn.bmj.com
Background Low-intensity focused ultrasound stimulation (LIFUS) has been developed to
enhance neurological repair and remodelling during the late acute stage of ischaemic stroke …

The role of circadian clock in astrocytes: From cellular functions to ischemic stroke therapeutic targets

Y Zhang, X Zhao, Y Zhang, F Zeng, S Yan… - Frontiers in …, 2022 - frontiersin.org
Accumulating evidence suggests that astrocytes, the abundant cell type in the central
nervous system (CNS), play a critical role in maintaining the immune response after cerebral …

The Roles of Non-coding RNA Targeting Astrocytes in Cerebral Ischemia

C Long, Z Li, W Song, X Zeng, R Yang, L Lu - Molecular Neurobiology, 2024 - Springer
Astrocytes are key targets for treating cerebral ischemia in the central nervous system. Non-
coding RNAs (ncRNAs) participate in the pathological processes of astrocytes in cerebral …

Social isolation initiated post-weaning augments ischemic brain injury by promoting pro-inflammatory responses

MF Dasdelen, AB Caglayan, S Er, MC Beker… - Experimental …, 2024 - Elsevier
Social isolation is associated with poor stroke outcome, but the underlying molecular
mechanisms were largely unknown. In male Balb/C mice exposed to transient middle …

Resveratrol Alleviates the Early Challenges of Implant-Based Drug Delivery in a Human Glial Cell Model

L Schlotterose, F Cossais, R Lucius… - International Journal of …, 2024 - mdpi.com
Brain diseases are oftentimes life-threatening and difficult to treat. The local administration of
drug substances using brain implants can increase on-site concentrations and decrease …

Neuroinflammation in post-ischemic brain

M Katarina Živančević, M Darko Lović… - Exon …, 2021 - exonpublications.com
Acute neuroinflammation occurring immediately after cerebral ischemia lasts for a few days.
Cytokines and chemokines promote the migration of neutrophils and macrophages to the …

Neurovascular coupling impairment as a mechanism for cognitive deficits in COVID-19

CD Owens, C Bonin Pinto, S Detwiler… - Brain …, 2024 - academic.oup.com
Components that comprise our brain parenchymal and cerebrovascular structures provide a
homeostatic environment for proper neuronal function to ensure normal cognition. Cerebral …

Folic acid deficiency exacerbates the inflammatory response of astrocytes after ischemia‐reperfusion by enhancing the interaction between IL‐6 and JAK‐1/pSTAT3

M Cheng, X Liang, L Shi, Q Zhang… - CNS Neuroscience …, 2023 - Wiley Online Library
Aim To demonstrate the role of IL‐6 and pSTAT3 in the inflammatory response to cerebral
ischemia/reperfusion following folic acid deficiency (FD). Methods The middle cerebral …

Synergistic amelioration between Ligusticum striatum DC and borneol against cerebral ischemia by promoting astrocytes–mediated neurogenesis

X Zhang, F Deng, X Wang, F Liu, Y Zhu, B Yu… - Journal of …, 2024 - Elsevier
Abstract Ethnopharmacological relevance Ligusticum chuanxiong Hort (LCH), with the
accepted name of Ligusticum striatum DC in “The Plant List” database, is a widely used …

Comprehensive Management of Stroke: From Mechanisms to Therapeutic Approaches

A Arnalich-Montiel, A Burgos-Santamaría… - International Journal of …, 2024 - mdpi.com
Acute ischemic stroke (AIS) is a challenging disease, which needs urgent comprehensive
management. Endovascular thrombectomy (EVT), alone or combined with iv thrombolysis, is …