Global, regional prevalence, and risk factors of osteoporosis according to the World Health Organization diagnostic criteria: a systematic review and meta-analysis
PL Xiao, AY Cui, CJ Hsu, R Peng, N Jiang… - Osteoporosis …, 2022 - Springer
This systematic review and meta-analysis estimated the global, regional prevalence, and
risk factors of osteoporosis. Prevalence varied greatly according to countries (from 4.1% in …
risk factors of osteoporosis. Prevalence varied greatly according to countries (from 4.1% in …
A road map for understanding molecular and genetic determinants of osteoporosis
Osteoporosis is a highly prevalent disorder characterized by low bone mineral density and
an increased risk of fracture, termed osteoporotic fracture. Notably, bone mineral density …
an increased risk of fracture, termed osteoporotic fracture. Notably, bone mineral density …
An atlas of genetic influences on osteoporosis in humans and mice
Osteoporosis is a common aging-related disease diagnosed primarily using bone mineral
density (BMD). We assessed genetic determinants of BMD as estimated by heel quantitative …
density (BMD). We assessed genetic determinants of BMD as estimated by heel quantitative …
[HTML][HTML] Twelve years of GWAS discoveries for osteoporosis and related traits: advances, challenges and applications
Osteoporosis is a common skeletal disease, affecting~ 200 million people around the world.
As a complex disease, osteoporosis is influenced by many factors, including diet (eg calcium …
As a complex disease, osteoporosis is influenced by many factors, including diet (eg calcium …
Genetic architecture: the shape of the genetic contribution to human traits and disease
Genetic architecture describes the characteristics of genetic variation that are responsible for
heritable phenotypic variability. It depends on the number of genetic variants affecting a trait …
heritable phenotypic variability. It depends on the number of genetic variants affecting a trait …
Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis
Osteoporosis is a common disease diagnosed primarily by measurement of bone mineral
density (BMD). We undertook a genome-wide association study (GWAS) in 142,487 …
density (BMD). We undertook a genome-wide association study (GWAS) in 142,487 …
Whole‐genome sequencing identifies EN1 as a determinant of bone density and fracture
The extent to which low‐frequency (minor allele frequency (MAF) between 1–5%) and rare
(MAF≤ 1%) variants contribute to complex traits and disease in the general population is …
(MAF≤ 1%) variants contribute to complex traits and disease in the general population is …
Assessment of the genetic and clinical determinants of fracture risk: genome wide association and mendelian randomisation study
Objectives To identify the genetic determinants of fracture risk and assess the role of 15
clinical risk factors on osteoporotic fracture risk. Design Meta-analysis of genome wide …
clinical risk factors on osteoporotic fracture risk. Design Meta-analysis of genome wide …
WNT1 Mutations in Early-Onset Osteoporosis and Osteogenesis Imperfecta
CM Laine, KS Joeng, PM Campeau… - … England Journal of …, 2013 - Mass Medical Soc
This report identifies human skeletal diseases associated with mutations in WNT1. In 10
family members with dominantly inherited, early-onset osteoporosis, we identified a …
family members with dominantly inherited, early-onset osteoporosis, we identified a …
The relevance of mouse models for investigating age-related bone loss in humans
RL Jilka - Journals of Gerontology Series A: Biomedical …, 2013 - academic.oup.com
Mice are increasingly used for investigation of the pathophysiology of osteoporosis because
their genome is easily manipulated, and their skeleton is similar to that of humans. Unlike …
their genome is easily manipulated, and their skeleton is similar to that of humans. Unlike …