Human renal dysplasia is a collection of disorders in which kidneys begin to form but then
fail to differentiate into normal nephrons and collecting ducts. Dysplasia is the principal …

The phenomenon of branching morphogenesis is a fundamental process critical for
development of several tubular organs including lung, mammary gland, and kidney. In the …

The expression of mitogen-activated protein kinases (MAPK) in DBA/2-pcy/pcy (pcy) mice, a
murine model of polycystic kidney disease was investigated. Proliferating cell nuclear …

Branching of ureteric bud-derived epithelial tubes is a key morphogenetic process that
shapes development of the kidney. Glial cell line-derived neurotrophic factor (GDNF) …

Activation of the ERK pathway precedes tubular proliferation in the obstructed rat kidney.
Background In vitro studies suggest that activation of the extracellular signal-regulated …

Abstract Background. Nephronophthisis (NPHP), the most frequent genetic cause of end-
stage kidney disease in children and young adults, is characterized by a variable number of …

Renal dysplasia and concurrent pyelonephritis were diagnosed in a 15‐week‐old female
Bull Mastiff which presented with clinical signs compatible with chronic renal failure …

Mitogen activated protein kinases (MAPKs) are intracellular signal transduction molecules,
which connect cell‐surface receptor signals to intracellular processes. MAPKs regulate a …

We previously reported that p38 mitogen-activated protein kinase (p38) and phosphorylated
ERK are upregulated in cyst epithelium of human renal dysplasia and obstructive uropathy …

Renal cell carcinoma (RCC) is asymptomatic at early stages, and thus, initial diagnosis
frequently occurs at advanced or even metastatic stages, leading to a high rate of mortality …