Microsatellite unstable (MSI) colorectal cancers (CRCs) are due to DNA mismatch repair
(MMR) deficiency and occurs in15% of non-metastatic diseases and 5% in the metastatic …

Objectives: To develop evidence-based guideline recommendations through a systematic
review of the literature to establish standard molecular biomarker testing of colorectal cancer …

Colorectal cancer (CRC) is the most common tumour type in both sexes combined in
Western countries. Although screening programmes including the implementation of faecal …

Microsatellite instability (MSI) is a molecular marker of a deficient mismatch repair (MMR)
system and occurs in approximately 15% of colorectal cancers (CRCs), more frequently in …

Research conducted during the past 30 years has increased our understanding of the
mechanisms involved in colorectal cancer initiation and development. The findings have …

Tumor DNA mismatch repair (MMR) deficiency testing is important to the identification of
Lynch syndrome and decision making regarding adjuvant chemotherapy in stage II …

Context Lynch syndrome is the most common form of hereditary colorectal cancer (CRC)
and is caused by germline mutations in DNA mismatch repair (MMR) genes. Identification of …

Colorectal cancer (CRC) accounts for over 8% of all deaths annually worldwide. Between 2
and 5% of all CRCs occur due to inherited syndromes, including Lynch syndrome, familial …

Various studies have presented clinical or in vitro evidence linking bacteria to colorectal
cancer, but these bacteria have not previously been concurrently quantified by qPCR in a …

Purpose: DNA mismatch repair (MMR) deficiency is a hallmark of Lynch syndrome, the most
common inherited cancer syndrome. MMR-deficient cancer cells accumulate numerous …