Irinotecan hydrochloride is a camptothecin derivative that exerts antitumor activity against a
variety of tumors. SN-38 produced in the body by carboxylesterase is the active metabolite of …

Aging involves progressive impairments in the functional reserve of multiple organs, which
might also affect drug metabolism and pharmacokinetics. In addition, the elderly population …

Fundamentals of Nursing provides you with all of the fundamental nursing concepts and
skills you will need as a beginning nurse in a visually appealing, easy-to-use format. We …

The American College of Critical Care Medicine (ACCM), which honors individuals for their
achievements and contributions to multidisciplinary critical care medicine, is the consultative …

Although no randomized studies have demonstrated a positive impact of therapeutic drug
monitoring (TDM) on clinical outcome in epilepsy, evidence from nonrandomized studies …

A revision of the 2008 British Association for Psychopharmacology evidence-based
guidelines for treating depressive disorders with antidepressants was undertaken in order to …

People are living to older age. Falls constitute a leading cause of injuries, hospitalization
and deaths among the elderly. Older people fall more often for a variety of reasons …

Population aging evokes doomsday economic and sociological prognostication, despite a
minority of older people suffering significant dependency and the potential for advances in …

The principles of inter‐species dose extrapolation are poorly understood and applied. We
provide an overview of the principles underlying dose scaling for size and dose adjustment …

The age-related changes in the functions and composition of the human body require
adjustments of drug selection and dosage for old individuals. Drug excretion via the kidneys …