Tumor microenvironment and immune evasion in head and neck squamous cell carcinoma

A Elmusrati, J Wang, CY Wang - International journal of oral science, 2021 - nature.com
Head and neck squamous cell carcinoma (HNSCC), an aggressive malignancy, is
characterized by high morbidity and low survival rates with limited therapeutic options …

[HTML][HTML] Essentials of oral cancer

C Rivera - International journal of clinical and experimental …, 2015 - ncbi.nlm.nih.gov
Oral cancer is one of the 10 most common cancers in the world, with a delayed clinical
detection, poor prognosis, without specific biomarkers for the disease and expensive …

The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of squamous cell carcinoma of the head and neck (HNSCC)

EEW Cohen, RB Bell, CB Bifulco, B Burtness… - … for immunotherapy of …, 2019 - Springer
Head and neck cancers, including those of the lip and oral cavity, nasal cavity, paranasal
sinuses, oropharynx, larynx and nasopharynx represent nearly 700,000 new cases and …

[HTML][HTML] Heterogeneity of the head and neck squamous cell carcinoma immune landscape and its impact on immunotherapy

M Canning, G Guo, M Yu, C Myint… - Frontiers in cell and …, 2019 - frontiersin.org
Head and neck squamous cell carcinomas (HNSCCs) are highly aggressive, multi-factorial
tumors in the upper aerodigestive tract affecting more than half a million patients worldwide …

[HTML][HTML] Mining TCGA database for genes of prognostic value in glioblastoma microenvironment

DI Jia, S Li, D Li, H Xue, D Yang, Y Liu - Aging (Albany NY), 2018 - ncbi.nlm.nih.gov
Glioblastoma (GBM) is one of the most deadly brain tumors. The convenient access to The
Cancer Genome Atlas (TCGA) database allows for large-scale global gene expression …

The prognostic role of tumor infiltrating T-lymphocytes in squamous cell carcinoma of the head and neck: A systematic review and meta-analysis

EJ de Ruiter, ML Ooft, LA Devriese… - Oncoimmunology, 2017 - Taylor & Francis
Background–The presence of tumor-infiltrating lymphocytes (TILs) in the tumor
microenvironment is associated with an improved prognosis and a better response to …

[HTML][HTML] Tumor angiogenesis: MMP-mediated induction of intravasation-and metastasis-sustaining neovasculature

EI Deryugina, JP Quigley - Matrix Biology, 2015 - Elsevier
Metastasis is a distinct stage of cancer progression that requires the development of
angiogenic blood vessels serving as conduits for tumor cell dissemination. An accumulated …

Tumor microenvironment: an evil nexus promoting aggressive head and neck squamous cell carcinoma and avenue for targeted therapy

AA Bhat, P Yousuf, NA Wani, A Rizwan… - Signal transduction and …, 2021 - nature.com
Head and neck squamous cell carcinoma (HNSCC) is a very aggressive disease with a poor
prognosis for advanced-stage tumors. Recent clinical, genomic, and cellular studies have …

Microenvironment-driven intratumoral heterogeneity in head and neck cancers: clinical challenges and opportunities for precision medicine

H Zaryouh, M Vara-Messler, J Vignau… - Drug Resistance …, 2022 - Elsevier
Squamous cell carcinoma of the head and neck (SCCHN) is among the most prevalent
cancer types worldwide. Despite multimodal therapeutic approaches that include surgical …

[HTML][HTML] Metastatic disease in head & neck oncology

P Pisani, M Airoldi, A Allais, PA Valletti… - Acta …, 2020 - ncbi.nlm.nih.gov
The head and neck district represents one of the most frequent sites of cancer, and the
percentage of metastases is very high in both loco-regional and distant areas. Prognosis …