Mitochondria undergo structural and functional remodeling to meet the cell demand in
response to the intracellular and extracellular stimulations, playing an essential role in …

Voltage-gated calcium channels (VGCCs) are the predominant source of calcium influx in
the heart leading to calcium-induced calcium release and ultimately excitation-contraction …

Abstract Objectives Cardiac Ca2+ signalling plays an essential role in regulating excitation‐
contraction coupling and cardiac remodelling. However, the response of cardiomyocytes to …

Abstract Growth differentiation factor 11 (GDF11) is a novel factor with controversial effects
on cardiac hypertrophy both in vivo and in vitro. Although recent evidence has corroborated …

Today, novel therapeutics are identified in an environment which is intrinsically different from
the clinical context in which they are ultimately evaluated. Using molecular phenotyping and …

Fluorosis is a worldwide public health problem, and its adverse effects on the heart have
been confirmed by many studies. Abnormal myocardial contractions are often associated …

Background Aberrant Ca2+ handling is a prominent feature of heart failure. Elucidation of
the molecular mechanisms responsible for aberrant Ca2+ handling is essential for the …

Ticagrelor is a direct acting and reversibly binding P2Y 12 antagonist approved for the
prevention of thromboembolic events. Clinical effects of ticagrelor cannot be simply …

Diabetes mellitus is a major global health disorder and, currently, over 450 million people
have diabetes with 90% suffering from type 2 diabetes. Left untreated, diabetes may lead to …

心肌细胞钙离子失去稳态调节是多种心脏病变的基础, 与缺血/再罐注(I/R) 损伤关系密切. I/R
引起细胞内外钙离子调节方式发生变化, 导致胞浆及线粒体基质钙超载; 通过能量依赖性肌纤维 …